CDH1
Gene Ontology Biological Process
- adherens junction organization [ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cellular response to amino acid stimulus [IDA]
- cellular response to indole-3-methanol [ISO]
- cellular response to lithium ion [ISO]
- cochlea development [IMP]
- epithelial cell morphogenesis [IMP]
- establishment of protein localization to plasma membrane [IDA, ISO]
- in utero embryonic development [IMP]
- intestinal epithelial cell development [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of epithelial cell proliferation [IMP]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein homooligomerization [IDA]
- protein localization to plasma membrane [ISO]
- protein metabolic process [IDA]
- regulation of branching involved in salivary gland morphogenesis [IMP]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of neuron migration [IDA]
- regulation of protein localization [IMP]
- regulation of protein localization to cell surface [IMP]
- regulation of water loss via skin [IMP]
- salivary gland cavitation [IMP]
- sensory perception of sound [IMP]
- single organismal cell-cell adhesion [IMP, ISO]
- synapse assembly [ISO]
- tight junction assembly [IMP]
- trophectodermal cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- actin cytoskeleton [ISO]
- adherens junction [IDA]
- aggresome [ISO]
- apical junction complex [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA]
- axon terminus [IDA]
- basolateral plasma membrane [IDA]
- catenin complex [IDA, ISO]
- cell junction [ISO]
- cell periphery [IDA]
- cell surface [IDA]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of membrane [ISO]
- lateral loop [IDA]
- lateral plasma membrane [ISO]
- node of Ranvier [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- trans-Golgi network [ISO]
NUMB
Gene Ontology Biological Process
- adherens junction organization [IGI]
- axonogenesis [IDA, IMP]
- forebrain development [IMP]
- lateral ventricle development [IMP]
- lung epithelial cell differentiation [IMP]
- negative regulation of Notch signaling pathway [IMP]
- negative regulation of protein localization to plasma membrane [ISO]
- nervous system development [IMP]
- neuroblast division in subventricular zone [IMP]
- neuroblast proliferation [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of neurogenesis [IMP]
- positive regulation of polarized epithelial cell differentiation [IMP]
- regulation of neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.
The polarity and adhesion of radial glial cells (RGCs), which function as progenitors and migrational guides for neurons, are critical for morphogenesis of the cerebral cortex. These characteristics largely depend on cadherin-based adherens junctions, which anchor apical end-feet of adjacent RGCs to each other at the ventricular surface. Here, we show that mouse numb and numb-like are required for maintaining ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NUMB CDH1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID