RTN4
Gene Ontology Biological Process
- aging [IEP]
- angiogenesis [ISO]
- axonal fasciculation [IDA, ISO]
- cardiac epithelial to mesenchymal transition [ISO]
- cerebral cortex radial glia guided migration [ISO, ISS]
- endoplasmic reticulum tubular network organization [ISO]
- negative regulation of axon extension [IDA, ISO, ISS]
- negative regulation of axonogenesis [IDA, IMP]
- negative regulation of cell growth [ISO]
- negative regulation of neuron differentiation [IDA]
- negative regulation of neuron projection development [IDA]
- negative regulation of neuron projection regeneration [IMP]
- nervous system development [ISO]
- olfactory nerve development [IEP]
- oligodendrocyte differentiation [IEP]
- positive regulation of dopamine secretion [IMP]
- positive regulation of glial cell differentiation [IDA]
- regulation of axon regeneration [IDA]
- regulation of branching morphogenesis of a nerve [IDA, ISO]
- regulation of cell migration [ISO]
- regulation of nervous system development [ISO]
- regulation of sensory perception of pain [IDA]
- response to activity [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell projection [ISO]
- cytoplasm [IDA]
- endoplasmic reticulum [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of endoplasmic reticulum membrane [IDA, ISO]
- integral component of membrane [TAS]
- intracellular [IDA, ISO]
- myelin sheath [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [ISO]
- nuclear envelope [ISO, ISS]
- plasma membrane [IDA]
- protein complex [IDA]
NDN
Gene Ontology Biological Process
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm.
Nogo-A has been identified in the central nervous system as an inhibitor for axonal regeneration. Previous works have mainly focused on Nogo-A in oligodendrocytes and the roles of neuronal intracellular Nogo-A remain elusive. To gain deep insight into the physiological functions of Nogo-A, a yeast two-hybrid screening was performed with Nogo-66 as bait. We identified a new interaction between Nogo-66 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RTN4 NDN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID