BAIT
RPL28
D7Wsu21e
ribosomal protein L28
GO Process (0)
GO Function (1)
GO Component (7)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
EFNA1
AI325262, B61, Efl1, Epl1, Eplg1, Lerk1
ephrin A1
GO Process (19)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- aortic valve morphogenesis [IMP]
- axon guidance [IBA]
- cell migration [ISO]
- endocardial cushion to mesenchymal transition involved in heart valve formation [IMP]
- ephrin receptor signaling pathway [IDA, ISO]
- mitral valve morphogenesis [IMP]
- negative regulation of dendritic spine morphogenesis [IDA]
- negative regulation of epithelial to mesenchymal transition [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neuron differentiation [IDA]
- notochord formation [IGI]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- regulation of angiogenesis [IDA]
- regulation of axonogenesis [IDA]
- regulation of blood vessel endothelial cell migration [IDA]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of peptidyl-tyrosine phosphorylation [IDA]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model posits that eIF6 release is triggered following phosphorylation of Ser 235 by activated protein kinase C. In contrast, genetic studies in yeast indicate a requirement for the ortholog of the SBDS (Shwachman-Bodian-Diamond syndrome) gene ... [more]
Genes Dev. May. 01, 2011; 25(9);917-29 [Pubmed: 21536732]
Throughput
- Low Throughput
Additional Notes
- RPL28 marks the 60S pre-ribosome; SBDS and EFL1 bind the 60-S independent of each other
Curated By
- BioGRID