BAIT
AKT1
Akt, PKB, PKB/Akt, PKBalpha, Rac
thymoma viral proto-oncogene 1
GO Process (82)
GO Function (15)
GO Component (12)
Gene Ontology Biological Process
- activation-induced cell death of T cells [ISO]
- aging [ISO]
- anagen [IMP]
- apoptotic mitochondrial changes [IDA]
- cell projection organization [ISO]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to hypoxia [ISO]
- cellular response to insulin stimulus [IDA, IMP, ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to organic cyclic compound [ISO]
- cellular response to peptide [IDA]
- cellular response to prostaglandin E stimulus [IDA]
- cytoskeleton organization [TAS]
- execution phase of apoptosis [IDA]
- germ cell development [IDA]
- glucose homeostasis [IMP]
- glucose metabolic process [IMP]
- glucose transport [IMP]
- glycogen biosynthetic process [ISO]
- glycogen cell differentiation involved in embryonic placenta development [IMP]
- glycogen metabolic process [IMP]
- inflammatory response [IDA]
- insulin receptor signaling pathway [IMP, ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- maternal placenta development [IMP]
- negative regulation of JNK cascade [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of autophagy [ISO]
- negative regulation of cell size [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of fatty acid beta-oxidation [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- osteoblast differentiation [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peripheral nervous system myelin maintenance [IMP]
- phosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of sodium ion transport [IDA, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of vasoconstriction [ISO]
- protein catabolic process [IDA]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [IGI]
- protein phosphorylation [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of cell migration [ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [IMP]
- regulation of neuron projection development [IDA]
- regulation of protein localization [IDA, ISO]
- response to UV-A [ISO]
- response to fluid shear stress [ISO]
- response to food [IDA]
- response to hormone [IDA]
- signal transduction [ISO]
- striated muscle cell differentiation [IGI]
- translation [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PPARGC1A
A830037N07Rik, ENSMUSG00000079510, Gm11133, PGC-1, PGC-1v, Pgc-1alpha, Pgc1, Pgco1, Ppargc1
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
GO Process (27)
GO Function (11)
GO Component (2)
Gene Ontology Biological Process
- cellular response to oxidative stress [IMP]
- circadian regulation of gene expression [IDA]
- mitochondrion organization [ISO]
- negative regulation of glycolytic process [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron death [ISO]
- negative regulation of receptor activity [ISO]
- negative regulation of smooth muscle cell migration [ISO]
- positive regulation of ATP biosynthetic process [IMP]
- positive regulation of cellular metabolic process [ISO]
- positive regulation of cellular respiration [IMP]
- positive regulation of energy homeostasis [IMP]
- positive regulation of fatty acid oxidation [IBA, ISO]
- positive regulation of mitochondrial DNA metabolic process [IMP]
- positive regulation of mitochondrion organization [IMP]
- positive regulation of muscle tissue development [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA, ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of circadian rhythm [IDA]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [ISO]
- respiratory electron transport chain [IDA]
- response to muscle activity [IDA, IMP]
- transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II transcription cofactor activity [IBA]
- chromatin DNA binding [IDA]
- chromatin binding [ISO]
- ligand-dependent nuclear receptor binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA, ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- transcription coactivator activity [IDA, IMP, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA]
- RNA polymerase II transcription cofactor activity [IBA]
- chromatin DNA binding [IDA]
- chromatin binding [ISO]
- ligand-dependent nuclear receptor binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA, ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- transcription coactivator activity [IDA, IMP, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.
Type 2 diabetes mellitus, a disease with significant effects on the health and economy of Western societies, involves disturbances in both lipid and carbohydrate metabolism. In the insulin-resistant or diabetic state, the liver is unresponsive to the actions of insulin with regard to the suppression of glucose output but continues to produce large amounts of lipid, the latter mimicking the ... [more]
Nature Jun. 21, 2007; 447(7147);1012-6 [Pubmed: 17554339]
Throughput
- Low Throughput
Additional Notes
- figure 1.
Curated By
- BioGRID