Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


TORC2 is required to maintain genome stability during the S phase in fission yeast.

Schonbrun M, Kolesnikov M, Kupiec M, Weisman R

DNA damage can occur due to environmental insults or intrinsic metabolic processes and is a major threat to genome stability. The DNA damage response is composed of a series of well coordinated cellular processes that include activation of the DNA damage checkpoint, transient cell cycle arrest, DNA damage repair and re-entrance into the cell cycle. Here we demonstrate that mutant ... [more]

J. Biol. Chem. May. 23, 2013; 0(0); [Pubmed: 23703609]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID