Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes.

Kiskinis E, Hallberg M, Christian M, Olofsson M, Dilworth SM, White R, Parker MG

Nuclear receptors control the function of cells by regulating transcription from specific gene networks. The establishment and maintenance of epigenetic gene marks is fundamental to the regulation of gene transcription and the control of cell function. RIP140 is a corepressor for nuclear receptors that suppresses transcription from a broad programme of metabolic genes and thereby controls energy homoeostasis in vivo. ... [more]

EMBO J. Nov. 28, 2007; 26(23);4831-40 [Pubmed: 17972916]

Throughput

  • Low Throughput

Additional Notes

  • figure 5.

Curated By

  • BioGRID