HSP90AB1
Gene Ontology Biological Process
- cellular response to interleukin-4 [IDA]
- negative regulation of neuron apoptotic process [ISO]
- placenta development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
Gene Ontology Cellular Component
ITGB1BP2
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1.
Melusin is a mammalian muscle specific CHORD containing protein capable of activating signal transduction pathways leading to cardiomyocytes hypertrophy in response to mechanical stress. To define melusin function we searched for molecular partners possibly involved in melusin dependent signal transduction. Here we show that melusin and heat shock proteins are co-regulated. Moreover, melusin directly binds to Hsp90, a ubiquitous chaperone ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 3. surface plasmon resonance (SPR) analysis
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITGB1BP2 HSP90AB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 861080 | |
| HSP90AB1 ITGB1BP2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 861081 |
Curated By
- BioGRID