CLN3
Gene Ontology Biological Process
- action potential [ISS]
- amyloid precursor protein catabolic process [IDA]
- arginine transport [IDA]
- associative learning [ISS]
- autophagic vacuole fusion [ISS]
- cellular amino acid metabolic process [ISS]
- ceramide metabolic process [IDA]
- cytosolic calcium ion homeostasis [ISS]
- galactosylceramide metabolic process [IMP]
- globoside metabolic process [IMP]
- glucosylceramide metabolic process [IMP]
- ionotropic glutamate receptor signaling pathway [ISS]
- lysosomal lumen acidification [IMP]
- lysosomal lumen pH elevation [IDA]
- lysosome organization [ISS]
- macroautophagy [NAS]
- membrane organization [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of catalytic activity [ISS]
- negative regulation of macroautophagy [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of proteolysis [ISS]
- neuromuscular process controlling balance [ISS]
- neurotransmitter metabolic process [ISS]
- protein catabolic process [NAS]
- protein processing [ISS]
- receptor-mediated endocytosis [IMP]
- sphingomyelin metabolic process [IMP]
- vacuolar transport [IBA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi membrane [IDA]
- Golgi stack [IDA]
- autophagic vacuole [ISS]
- caveola [IDA]
- cytoplasm [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- integral component of membrane [IDA]
- late endosome [IDA, ISS]
- lysosomal membrane [IDA]
- lysosome [IDA]
- membrane raft [IDA]
- mitochondrion [TAS]
- neuron projection [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- synaptic vesicle [IDA]
- trans-Golgi network [IDA]
HSD17B12
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach.
Neuronal ceroid lipofuscinoses (NCL) are the most common inherited progressive encephalopathies of childhood. One of the most prevalent forms of NCL, Juvenile neuronal ceroid lipofuscinosis (JNCL) or CLN3 disease (OMIM: 204200) is caused by mutations in the CLN3 gene on chromosome 16p12.1. Despite progress in the NCL field, the primary function of ceroid-lipofuscinosis neuronal protein 3 (CLN3) remains elusive. In ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLN3 HSD17B12 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 446049 |
Curated By
- BioGRID