BAIT
CD81
CVID6, S5.7, TAPA1, TSPAN28
CD81 molecule
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- cell proliferation [TAS]
- phosphatidylinositol biosynthetic process [IDA]
- phosphatidylinositol metabolic process [IDA]
- positive regulation of 1-phosphatidylinositol 4-kinase activity [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- protein localization [IDA]
- receptor-mediated virion attachment to host cell [TAS]
- regulation of immune response [TAS]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAC2
EN-7, Gx, HSPC022, p21-Rac2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
GO Process (14)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- actin filament organization [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- lymphocyte aggregation [IMP]
- platelet activation [TAS]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of neutrophil chemotaxis [IMP]
- regulation of cell-substrate adhesion [IMP]
- regulation of hydrogen peroxide metabolic process [TAS]
- regulation of neutrophil migration [IMP]
- regulation of respiratory burst [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes.
Extracellular vesicles are emerging as a potent mechanism of intercellular communication because they can systemically exchange genetic and protein material between cells. Tetraspanin molecules are commonly used as protein markers of extracellular vesicles, although their role in the unexplored mechanisms of cargo selection into exosomes has not been addressed. For that purpose, we have characterized the intracellular tetraspanin-enriched microdomain (TEM) ... [more]
J. Biol. Chem. Apr. 26, 2013; 288(17);11649-61 [Pubmed: 23463506]
Throughput
- High Throughput
Curated By
- BioGRID