BAIT
SMG1
61E3.4, ATX, LIP
SMG1 phosphatidylinositol 3-kinase-related kinase
GO Process (10)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- double-strand break repair via homologous recombination [IBA]
- gene expression [TAS]
- mRNA export from nucleus [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IDA, NAS, TAS]
- peptidyl-serine phosphorylation [IDA, TAS]
- phosphatidylinositol phosphorylation [IDA]
- protein autophosphorylation [IDA]
- response to stress [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
HSPA4
APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
heat shock 70kDa protein 4
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.
Phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins play essential roles in DNA-based and RNA-based processes, such as the response to DNA damage, messenger RNA (mRNA) quality control, transcription, and translation, where they contribute to the maintenance of genome integrity and accurate gene expression. The adenosine triphosphatases associated with diverse cellular activities (AAA+) family proteins RuvB-like 1 (RUVBL1) and RUVBL2 are ... [more]
Sci Signal Apr. 08, 2010; 3(116);ra27 [Pubmed: 20371770]
Throughput
- Low Throughput
Curated By
- BioGRID