MAPK7
Gene Ontology Biological Process
- MAPK cascade [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to laminar fluid shear stress [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of heterotypic cell-cell adhesion [ISO]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of response to cytokine stimulus [ISO]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of protein metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of angiogenesis [IMP]
Gene Ontology Molecular Function
HSP90AB1
Gene Ontology Biological Process
- cellular response to interleukin-4 [IDA]
- negative regulation of neuron apoptotic process [ISO]
- placenta development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Complex.
The mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase 5 (ERK5) plays a crucial role in cell proliferation, regulating gene transcription. ERK5 has a unique C-terminal tail which contains a transcriptional activation domain, and activates transcription by phosphorylating transcription factors and acting itself as a transcriptional coactivator. However, the molecular mechanisms that regulate its nucleocytoplasmatic traffic are unknown. We have used ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID