BAIT
PLCB1
PLC'1, PLCbeta1, Phosphb, RATPHOSPHB
phospholipase C, beta 1 (phosphoinositide-specific)
GO Process (30)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- activation of meiosis involved in egg activation [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- fat cell differentiation [ISO]
- glutamate receptor signaling pathway [ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- interleukin-1-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- interleukin-15-mediated signaling pathway [ISO]
- learning [IEP]
- memory [IEP, ISO]
- negative regulation of monocyte extravasation [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- phosphatidylinositol metabolic process [IEP]
- positive regulation of CD24 biosynthetic process [ISO, ISS]
- positive regulation of G1/S transition of mitotic cell cycle [ISO, ISS]
- positive regulation of GTPase activity [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of acrosome reaction [ISO]
- positive regulation of developmental growth [ISO, ISS]
- positive regulation of embryonic development [ISO]
- positive regulation of interleukin-12 production [ISO, ISS]
- positive regulation of myoblast differentiation [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- regulation of G-protein coupled receptor protein signaling pathway [ISO, ISS]
- regulation of fertilization [ISO]
- response to monosaccharide [IDA]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
APEX1
APE, Apex, HAP1, Ref-1
apurinic/apyrimidinic endonuclease 1
GO Process (15)
GO Function (14)
GO Component (9)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IBA, ISO]
- DNA catabolic process, exonucleolytic [IBA]
- DNA demethylation [ISO]
- DNA repair [ISO]
- RNA phosphodiester bond hydrolysis, endonucleolytic [ISO]
- aging [ISO]
- base-excision repair [IBA]
- cell redox homeostasis [IDA]
- cellular response to hydrogen peroxide [ISO]
- negative regulation of smooth muscle cell migration [ISO]
- oxidation-reduction process [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of mRNA stability [ISO]
- regulation of nucleic acid-templated transcription [ISO]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [ISO]
- DNA binding [ISO]
- DNA-(apurinic or apyrimidinic site) lyase activity [IBA, ISO]
- NF-kappaB binding [ISO]
- chromatin DNA binding [ISO]
- damaged DNA binding [ISO]
- double-stranded DNA 3'-5' exodeoxyribonuclease activity [IBA]
- endoribonuclease activity [ISO]
- metal ion binding [ISO]
- oxidoreductase activity [ISO]
- poly(A) RNA binding [ISO]
- protein complex binding [ISO]
- site-specific endodeoxyribonuclease activity, specific for altered base [ISO]
- transcription coactivator activity [ISO]
- 3'-5' exonuclease activity [ISO]
- DNA binding [ISO]
- DNA-(apurinic or apyrimidinic site) lyase activity [IBA, ISO]
- NF-kappaB binding [ISO]
- chromatin DNA binding [ISO]
- damaged DNA binding [ISO]
- double-stranded DNA 3'-5' exodeoxyribonuclease activity [IBA]
- endoribonuclease activity [ISO]
- metal ion binding [ISO]
- oxidoreductase activity [ISO]
- poly(A) RNA binding [ISO]
- protein complex binding [ISO]
- site-specific endodeoxyribonuclease activity, specific for altered base [ISO]
- transcription coactivator activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphoinositide-specific Phospholipase C Interactome: Affinity Purification-Mass Spectrometry analysis of PI-PLCβ1b association with nuclear proteins.
Two isoforms of inositide-dependent phospholipase Cβ1 (PI-PLCβ1) are generated by alternative splicing (PLCβ1a and PLCβ1b). Both isoforms are present within the nucleus, but in contrast to PLCβ1a, the vast majority of PLCβ1b is nuclear. In mouse erythroid leukemia (MEL) cells, PI-PLCβ1 is involved in the regulation of cell division and the balance between cell proliferation and differentiation. It has been ... [more]
Mol. Cell Proteomics May. 09, 2013; 0(0); [Pubmed: 23665500]
Throughput
- High Throughput
Curated By
- BioGRID