BAIT
PLCB1
PLC'1, PLCbeta1, Phosphb, RATPHOSPHB
phospholipase C, beta 1 (phosphoinositide-specific)
GO Process (30)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- activation of meiosis involved in egg activation [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- fat cell differentiation [ISO]
- glutamate receptor signaling pathway [ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- interleukin-1-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- interleukin-15-mediated signaling pathway [ISO]
- learning [IEP]
- memory [IEP, ISO]
- negative regulation of monocyte extravasation [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- phosphatidylinositol metabolic process [IEP]
- positive regulation of CD24 biosynthetic process [ISO, ISS]
- positive regulation of G1/S transition of mitotic cell cycle [ISO, ISS]
- positive regulation of GTPase activity [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of acrosome reaction [ISO]
- positive regulation of developmental growth [ISO, ISS]
- positive regulation of embryonic development [ISO]
- positive regulation of interleukin-12 production [ISO, ISS]
- positive regulation of myoblast differentiation [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- regulation of G-protein coupled receptor protein signaling pathway [ISO, ISS]
- regulation of fertilization [ISO]
- response to monosaccharide [IDA]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CDC42
AI747189, AU018915, RP23-246F18.2
cell division cycle 42
GO Process (50)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [ISA]
- Golgi organization [ISO]
- Rho protein signal transduction [TAS]
- actin filament branching [ISO]
- actin filament bundle assembly [IMP]
- actin filament organization [ISO]
- adherens junction organization [IMP]
- canonical Wnt signaling pathway [IMP]
- cardiac conduction system development [IGI]
- cellular protein localization [IMP]
- dendritic cell migration [IGI]
- endosomal transport [TAS]
- epidermis morphogenesis [IMP]
- epithelial cell-cell adhesion [IMP]
- epithelial-mesenchymal cell signaling [IMP]
- establishment of Golgi localization [ISO]
- establishment or maintenance of apical/basal cell polarity [IMP]
- establishment or maintenance of cell polarity [TAS]
- filopodium assembly [IDA]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IMP]
- heart contraction [IGI]
- keratinization [IMP]
- keratinocyte development [IMP]
- multicellular organism growth [IMP]
- negative regulation of gene expression [IMP]
- neuron fate determination [IMP]
- nuclear migration [IMP]
- nucleus localization [IMP]
- organelle transport along microtubule [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of hair follicle cell proliferation [IMP]
- positive regulation of intracellular protein transport [ISO]
- positive regulation of metalloenzyme activity [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of synapse structural plasticity [ISO]
- regulation of mitosis [IMP]
- regulation of protein catabolic process [IMP]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein kinase activity [IMP]
- regulation of protein metabolic process [IMP]
- regulation of protein stability [IMP]
- single organismal cell-cell adhesion [IMP, TAS]
- sprouting angiogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphoinositide-specific Phospholipase C Interactome: Affinity Purification-Mass Spectrometry analysis of PI-PLCβ1b association with nuclear proteins.
Two isoforms of inositide-dependent phospholipase Cβ1 (PI-PLCβ1) are generated by alternative splicing (PLCβ1a and PLCβ1b). Both isoforms are present within the nucleus, but in contrast to PLCβ1a, the vast majority of PLCβ1b is nuclear. In mouse erythroid leukemia (MEL) cells, PI-PLCβ1 is involved in the regulation of cell division and the balance between cell proliferation and differentiation. It has been ... [more]
Mol. Cell Proteomics May. 09, 2013; 0(0); [Pubmed: 23665500]
Throughput
- High Throughput
Curated By
- BioGRID