BAIT
PLCB1
PLC'1, PLCbeta1, Phosphb, RATPHOSPHB
phospholipase C, beta 1 (phosphoinositide-specific)
GO Process (30)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- activation of meiosis involved in egg activation [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- fat cell differentiation [ISO]
- glutamate receptor signaling pathway [ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- interleukin-1-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- interleukin-15-mediated signaling pathway [ISO]
- learning [IEP]
- memory [IEP, ISO]
- negative regulation of monocyte extravasation [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- phosphatidylinositol metabolic process [IEP]
- positive regulation of CD24 biosynthetic process [ISO, ISS]
- positive regulation of G1/S transition of mitotic cell cycle [ISO, ISS]
- positive regulation of GTPase activity [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of acrosome reaction [ISO]
- positive regulation of developmental growth [ISO, ISS]
- positive regulation of embryonic development [ISO]
- positive regulation of interleukin-12 production [ISO, ISS]
- positive regulation of myoblast differentiation [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- regulation of G-protein coupled receptor protein signaling pathway [ISO, ISS]
- regulation of fertilization [ISO]
- response to monosaccharide [IDA]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
FLNA
ABP-280, Dilp2, F730004A14Rik, Fln1, GENA 379, filamin-1, RP23-436K3.1
filamin, alpha
GO Process (19)
GO Function (16)
GO Component (18)
Gene Ontology Biological Process
- actin crosslink formation [ISO]
- actin cytoskeleton organization [IGI]
- actin cytoskeleton reorganization [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [ISO]
- cilium assembly [ISO]
- cytoplasmic sequestering of protein [ISO]
- early endosome to late endosome transport [IDA]
- epithelial to mesenchymal transition [IGI]
- establishment of protein localization [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- platelet aggregation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- protein localization to cell surface [ISO]
- protein stabilization [ISO]
- receptor clustering [ISO]
- spindle assembly involved in mitosis [ISO]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Myb complex [ISO]
- actin cytoskeleton [ISO]
- actin filament [ISO]
- actin filament bundle [IDA]
- apical dendrite [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic shaft [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- trans-Golgi network [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphoinositide-specific Phospholipase C Interactome: Affinity Purification-Mass Spectrometry analysis of PI-PLCβ1b association with nuclear proteins.
Two isoforms of inositide-dependent phospholipase Cβ1 (PI-PLCβ1) are generated by alternative splicing (PLCβ1a and PLCβ1b). Both isoforms are present within the nucleus, but in contrast to PLCβ1a, the vast majority of PLCβ1b is nuclear. In mouse erythroid leukemia (MEL) cells, PI-PLCβ1 is involved in the regulation of cell division and the balance between cell proliferation and differentiation. It has been ... [more]
Mol. Cell Proteomics May. 09, 2013; 0(0); [Pubmed: 23665500]
Throughput
- High Throughput
Curated By
- BioGRID