BAIT
PLCB1
PLC'1, PLCbeta1, Phosphb, RATPHOSPHB
phospholipase C, beta 1 (phosphoinositide-specific)
GO Process (30)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- activation of meiosis involved in egg activation [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- fat cell differentiation [ISO]
- glutamate receptor signaling pathway [ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- interleukin-1-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- interleukin-15-mediated signaling pathway [ISO]
- learning [IEP]
- memory [IEP, ISO]
- negative regulation of monocyte extravasation [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- phosphatidylinositol metabolic process [IEP]
- positive regulation of CD24 biosynthetic process [ISO, ISS]
- positive regulation of G1/S transition of mitotic cell cycle [ISO, ISS]
- positive regulation of GTPase activity [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of acrosome reaction [ISO]
- positive regulation of developmental growth [ISO, ISS]
- positive regulation of embryonic development [ISO]
- positive regulation of interleukin-12 production [ISO, ISS]
- positive regulation of myoblast differentiation [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- regulation of G-protein coupled receptor protein signaling pathway [ISO, ISS]
- regulation of fertilization [ISO]
- response to monosaccharide [IDA]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PRDX2
AL022839, Band-8, NkefB, PRP, PrxII, TDX1, TPx, TPx-B, TR, TSA, Tdpx1, Torin
peroxiredoxin 2
GO Process (22)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- T cell proliferation [IMP]
- activation of MAPK activity [IMP]
- cellular response to oxidative stress [ISO]
- homeostasis of number of cells [IMP]
- hydrogen peroxide catabolic process [IMP]
- hydrogen peroxide metabolic process [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of T cell differentiation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- oxidation-reduction process [ISS]
- positive regulation of blood coagulation [IMP]
- regulation of apoptotic process [ISO]
- regulation of hydrogen peroxide metabolic process [IMP]
- removal of superoxide radicals [IMP, ISO]
- respiratory burst involved in inflammatory response [IMP]
- response to lipopolysaccharide [IMP]
- response to oxidative stress [ISO, TAS]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphoinositide-specific Phospholipase C Interactome: Affinity Purification-Mass Spectrometry analysis of PI-PLCβ1b association with nuclear proteins.
Two isoforms of inositide-dependent phospholipase Cβ1 (PI-PLCβ1) are generated by alternative splicing (PLCβ1a and PLCβ1b). Both isoforms are present within the nucleus, but in contrast to PLCβ1a, the vast majority of PLCβ1b is nuclear. In mouse erythroid leukemia (MEL) cells, PI-PLCβ1 is involved in the regulation of cell division and the balance between cell proliferation and differentiation. It has been ... [more]
Mol. Cell Proteomics May. 09, 2013; 0(0); [Pubmed: 23665500]
Throughput
- High Throughput
Curated By
- BioGRID