BAIT
PLCB1
PLC'1, PLCbeta1, Phosphb, RATPHOSPHB
phospholipase C, beta 1 (phosphoinositide-specific)
GO Process (30)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- activation of meiosis involved in egg activation [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- fat cell differentiation [ISO]
- glutamate receptor signaling pathway [ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- interleukin-1-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- interleukin-15-mediated signaling pathway [ISO]
- learning [IEP]
- memory [IEP, ISO]
- negative regulation of monocyte extravasation [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- phosphatidylinositol metabolic process [IEP]
- positive regulation of CD24 biosynthetic process [ISO, ISS]
- positive regulation of G1/S transition of mitotic cell cycle [ISO, ISS]
- positive regulation of GTPase activity [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of acrosome reaction [ISO]
- positive regulation of developmental growth [ISO, ISS]
- positive regulation of embryonic development [ISO]
- positive regulation of interleukin-12 production [ISO, ISS]
- positive regulation of myoblast differentiation [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- regulation of G-protein coupled receptor protein signaling pathway [ISO, ISS]
- regulation of fertilization [ISO]
- response to monosaccharide [IDA]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SMARCA4
Brg1, HP1-BP72, SNF2beta, SW1/SNF, b2b508.1Clo, b2b692Clo
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
GO Process (48)
GO Function (19)
GO Component (13)
Gene Ontology Biological Process
- ATP catabolic process [IMP, ISO]
- ATP-dependent chromatin remodeling [ISO]
- DNA methylation on cytosine within a CG sequence [IMP]
- aortic smooth muscle cell differentiation [IMP]
- blastocyst growth [IMP]
- blastocyst hatching [IMP]
- blood vessel development [IMP]
- cell morphogenesis [IMP]
- chromatin remodeling [IMP, ISO]
- definitive erythrocyte differentiation [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic organ morphogenesis [IMP]
- epidermis morphogenesis [IMP]
- extracellular matrix organization [IMP]
- forebrain development [IMP]
- glial cell fate determination [IMP]
- heart development [IMP]
- heart trabecula formation [IGI]
- hindbrain development [IMP]
- histone H3 acetylation [IMP]
- in utero embryonic development [IMP]
- keratinocyte differentiation [IMP]
- lens fiber cell development [IMP]
- liver development [IMP]
- methylation-dependent chromatin silencing [IDA]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [ISO]
- nervous system development [IMP]
- neurogenesis [IDA]
- nucleosome assembly [TAS]
- nucleosome disassembly [ISO]
- outflow tract morphogenesis [IMP]
- pharyngeal arch artery morphogenesis [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA binding [IGI]
- positive regulation of Wnt signaling pathway [IMP, ISO]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell migration [IMP]
- stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- ATPase activity [IMP, TAS]
- DNA polymerase binding [IPI, ISO]
- DNA-dependent ATPase activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- Tat protein binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA, ISO]
- lysine-acetylated histone binding [ISO]
- nucleosomal DNA binding [ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI]
- ATPase activity [IMP, TAS]
- DNA polymerase binding [IPI, ISO]
- DNA-dependent ATPase activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- Tat protein binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA, ISO]
- lysine-acetylated histone binding [ISO]
- nucleosomal DNA binding [ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphoinositide-specific Phospholipase C Interactome: Affinity Purification-Mass Spectrometry analysis of PI-PLCβ1b association with nuclear proteins.
Two isoforms of inositide-dependent phospholipase Cβ1 (PI-PLCβ1) are generated by alternative splicing (PLCβ1a and PLCβ1b). Both isoforms are present within the nucleus, but in contrast to PLCβ1a, the vast majority of PLCβ1b is nuclear. In mouse erythroid leukemia (MEL) cells, PI-PLCβ1 is involved in the regulation of cell division and the balance between cell proliferation and differentiation. It has been ... [more]
Mol. Cell Proteomics May. 09, 2013; 0(0); [Pubmed: 23665500]
Throughput
- High Throughput
Curated By
- BioGRID