ACE
Gene Ontology Biological Process
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- arachidonic acid secretion [ISO]
- bradykinin catabolic process [ISO]
- eating behavior [ISO]
- heart contraction [IMP]
- hormone catabolic process [IDA, ISO]
- kidney development [IMP, ISO]
- lung alveolus development [ISO]
- negative regulation of calcium ion import [ISO]
- neutrophil mediated immunity [IMP]
- organ regeneration [ISO]
- peptide catabolic process [ISO]
- peptide metabolic process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of neurogenesis [ISO]
- positive regulation of systemic arterial blood pressure [IMP, ISO]
- proteolysis [IMP, ISO]
- regulation of blood pressure [IDA, ISO]
- regulation of smooth muscle cell migration [ISO]
- response to lipopolysaccharide [ISO]
- sensory perception of pain [ISO]
- spermatogenesis [IMP]
- vasoconstriction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYH9
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- actin cytoskeleton reorganization [ISO]
- actin filament-based movement [ISO]
- actomyosin structure organization [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- cell adhesion [IMP]
- cell morphogenesis involved in differentiation [IMP]
- cellular component movement [IMP]
- cytokinesis [ISO]
- establishment of T cell polarity [IMP]
- establishment of meiotic spindle localization [IDA]
- in utero embryonic development [IMP]
- meiotic spindle organization [IDA]
- membrane protein ectodomain proteolysis [ISO]
- myoblast fusion [IMP]
- platelet aggregation [ISO]
- platelet formation [ISO]
- protein transport [ISO]
- regulation of cell shape [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- uropod organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- actin cytoskeleton [ISO]
- actomyosin [ISO]
- actomyosin contractile ring [ISO]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell adherens junction [IDA]
- cleavage furrow [ISO]
- cortical cytoskeleton [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA, ISO]
- integrin complex [ISO]
- membrane [ISO]
- myosin II complex [IDA, ISO]
- myosin II filament [ISO]
- myosin complex [IDA]
- neuromuscular junction [IDA]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- ruffle [ISO]
- spindle [IDA]
- stress fiber [IDA, ISO]
- uropod [IDA, ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Signaling via the angiotensin-converting enzyme results in the phosphorylation of the nonmuscle myosin heavy chain IIA.
The phosphorylation of the short C-terminal cytoplasmic domain of the somatic angiotensin-converting enzyme (ACE) is involved in the regulation of enzyme shedding. We determined whether the phosphorylation of the cytoplasmic domain of ACE (ACEct) on Ser1270 regulates the cleavage/secretion of the enzyme by affecting its association with other proteins. ACE was associated with beta-actin and the nonmuscle myosin heavy chain ... [more]
Throughput
- Low Throughput
Ontology Terms
- tissue: lung (UBERON:0002048)
- tissue: lung (BTO:0000763)
Additional Notes
- interaction detected in mouse lung
Curated By
- BioGRID