MXD4
Gene Ontology Biological Process
Gene Ontology Molecular Function
SIN3A
Gene Ontology Biological Process
- DNA replication [IMP]
- activation of innate immune response [ISO]
- aging [ISO]
- cellular protein localization [IMP]
- cellular response to glucose stimulus [IDA]
- hematopoietic progenitor cell differentiation [IMP]
- histone deacetylation [IBA]
- in utero embryonic development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of circadian rhythm [IMP]
- negative regulation of histone H3-K27 acetylation [ISO]
- negative regulation of protein localization to nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription regulatory region DNA binding [ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of chromatin silencing [ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein deacetylation [ISO]
- regulation of hormone levels [ISO]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [IMP]
- response to methylglyoxal [IDA]
- response to organonitrogen compound [ISO]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IGI]
- chromatin binding [IDA]
- histone deacetylase activity [IBA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IGI]
- chromatin binding [IDA]
- histone deacetylase activity [IBA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.
The basic helix-loop-helix-leucine zipper (bHLHZip) protein Max associates with members of the Myc family, as well as with the related proteins Mad (Mad1) and Mxi1. Whereas both Myc:Max and Mad:Max heterodimers bind related E-box sequences, Myc:Max activates transcription and promotes proliferation while Mad:Max represses transcription and suppresses Myc dependent transformation. Here we report the identification and characterization of two novel ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID