BAIT
CBK1
CaO19.12375, CaO6.3756, CAWG_00395, CA2022, orf19.4909, orf6.3756, CaO19.4909, Contig4-2855_0009, C1_10380C, orf19.12375, IPF9611.2, C1_10380C_B, IPF22379.1, C1_10380C_A
Ser/Thr kinase of cell wall integrity pathway; mutants show abnormal morphology and aggregation; Mob2p associated; required for wild-type hyphal growth and transcriptional regulation of cell-wall-associated genes
GO Process (0)
GO Function (0)
GO Component (0)
Candida albicans (SC5314)
PREY
RPL15A
Contig4-2904_0008, orf19.493, CaO6.269, orf6.269, orf6.7078, CR_04100C_B, CR_04100C, CA0042, RPL15, CA4512, orf19.8123, CaO19.493, CAWG_01747, RPL15B, IPF8963.2, CaO19.8123, CaO6.7078, IPF15914.3, CR_04100C_A
Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed
GO Process (0)
GO Function (0)
GO Component (0)
Candida albicans (SC5314)
Synthetic Haploinsufficiency
A genetic interaction is inferred when mutations or deletions in separate genes, at least one of which is hemizygous, cause a minimal phenotype alone but result in lethality when combined in the same cell under a given condition.
Publication
A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis.
The morphogenetic transition between yeast and filamentous forms of the human fungal pathogen Candida albicans is regulated by a variety of signaling pathways. How these pathways interact to orchestrate morphogenesis, however, has not been as well characterized. To address this question and to identify genes that interact with the Regulation of Ace2 and Morphogenesis (RAM) pathway during filamentation, we report ... [more]
PLoS Genet. Apr. 01, 2011; 7(4);e1002058 [Pubmed: 22103005]
Throughput
- High Throughput
Ontology Terms
- filamentous growth (APO:0000027)
Additional Notes
- A heterozygous mutant of CBK1, was subjected to transposon-mediated, insertional mutagenesis.
Curated By
- BioGRID