BAIT
MAPK3
Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3, p44, p44erk1, p44mapk
mitogen-activated protein kinase 3
GO Process (35)
GO Function (6)
GO Component (15)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- DNA damage induced protein phosphorylation [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [ISO]
- cartilage development [IDA]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- interleukin-1-mediated signaling pathway [ISO]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of apolipoprotein binding [IMP]
- organ morphogenesis [IDA]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-tyrosine autophosphorylation [ISO]
- phosphorylation [ISO, TAS]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of translation [ISO]
- protein complex assembly [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to toxic substance [ISO]
- sensory perception of pain [IMP]
- signal transduction [TAS]
- transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- caveola [TAS]
- cytoplasm [IDA]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [TAS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, TAS]
- protein complex [ISO]
- pseudopodium [IDA]
Mus musculus
PREY
ATF2
Atf-2, CRE-BP, Creb2, D130078H02Rik, D18875, Tg(Gzma-Klra1)7Wum, mXBP, RP23-290B1.2
activating transcription factor 2
GO Process (13)
GO Function (15)
GO Component (6)
Gene Ontology Biological Process
- adipose tissue development [IGI]
- cellular response to DNA damage stimulus [ISO]
- fat cell differentiation [IGI]
- histone acetylation [ISO]
- intra-S DNA damage checkpoint [ISO]
- outflow tract morphogenesis [IMP]
- positive regulation of mitochondrial membrane permeability involved in apoptotic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transforming growth factor beta2 production [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to osmotic stress [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- cAMP response element binding [ISO]
- cAMP response element binding protein binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [ISO]
- histone acetyltransferase activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- cAMP response element binding [ISO]
- cAMP response element binding protein binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [ISO]
- histone acetyltransferase activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells.
Activating transcription factor 2 (ATF2) has been shown to regulate gene expression in the cellular response to environmental stresses such as ultraviolet (UV) irradiation. However, the signal transduction mechanism of ATF2 activation by UV is not as yet completely understood. In the present study, we provide evidence showing that UVC-stimulated phosphorylation of ATF2 (Thr71) was to varying degrees prevented by ... [more]
Carcinogenesis Oct. 01, 2004; 25(10);1847-52 [Pubmed: 15192015]
Throughput
- Low Throughput
Curated By
- BioGRID