RPS6KA5
Gene Ontology Biological Process
- histone H2A-S1 phosphorylation [ISO]
- histone H3-S10 phosphorylation [ISO, ISS]
- histone H3-S28 phosphorylation [ISO, ISS]
- histone phosphorylation [ISO]
- interleukin-1-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
Gene Ontology Molecular Function
ATF2
Gene Ontology Biological Process
- adipose tissue development [IGI]
- cellular response to DNA damage stimulus [ISO]
- fat cell differentiation [IGI]
- histone acetylation [ISO]
- intra-S DNA damage checkpoint [ISO]
- outflow tract morphogenesis [IMP]
- positive regulation of mitochondrial membrane permeability involved in apoptotic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transforming growth factor beta2 production [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to osmotic stress [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- cAMP response element binding [ISO]
- cAMP response element binding protein binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [ISO]
- histone acetyltransferase activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- cAMP response element binding [ISO]
- cAMP response element binding protein binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [ISO]
- histone acetyltransferase activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells.
Activating transcription factor 2 (ATF2) has been shown to regulate gene expression in the cellular response to environmental stresses such as ultraviolet (UV) irradiation. However, the signal transduction mechanism of ATF2 activation by UV is not as yet completely understood. In the present study, we provide evidence showing that UVC-stimulated phosphorylation of ATF2 (Thr71) was to varying degrees prevented by ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RPS6KA5 ATF2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID