BAIT
MVK
Lrbp
mevalonate kinase
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- cholesterol biosynthetic process [ISO, TAS]
- isopentenyl diphosphate biosynthetic process, mevalonate pathway [IDA]
- isoprenoid biosynthetic process [IDA, ISO]
- isoprenoid metabolic process [TAS]
- negative regulation of inflammatory response [ISO]
- negative regulation of translation [IDA]
- regulation of cholesterol biosynthetic process [NAS]
- sterol metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HSPA5
BIP, GRP78
heat shock protein 5
GO Process (16)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- ER overload response [ISO]
- activation of signaling protein activity involved in unfolded protein response [ISO]
- cellular response to antibiotic [IEP]
- cellular response to glucose starvation [ISO]
- cellular response to interleukin-4 [ISO]
- cerebellar Purkinje cell layer development [ISO]
- cerebellum structural organization [ISO]
- maintenance of protein localization in endoplasmic reticulum [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of protein ubiquitination [ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
- response to endoplasmic reticulum stress [IDA]
- substantia nigra development [ISO]
- toxin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- cell surface [ISO]
- endoplasmic reticulum [IDA, ISO, TAS]
- endoplasmic reticulum chaperone complex [ISO]
- endoplasmic reticulum lumen [ISO]
- endoplasmic reticulum membrane [ISO]
- endoplasmic reticulum-Golgi intermediate compartment [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of endoplasmic reticulum membrane [ISO]
- membrane [IDA, ISO]
- midbody [ISO]
- mitochondrion [IDA]
- myelin sheath [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- smooth endoplasmic reticulum [IDA]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries.
Luteinizing hormone receptor (LHR) mRNA binding protein (LRBP), identified as mevalonate kinase, has been shown to be a trans factor mediating the post-transcriptional regulation of LHR mRNA expression in ovaries. LRBP binds to the coding region of LHR mRNA and accelerates its degradation. Our previous studies in an in vitro system showed that LRBP represses the translation of LHR mRNA ... [more]
Biochim. Biophys. Acta May. 01, 2010; 1803(5);591-7 [Pubmed: 20167237]
Throughput
- Low Throughput
Curated By
- BioGRID