SHC1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [ISO]
- actin cytoskeleton reorganization [IMP]
- activation of MAPK activity [IMP, ISO]
- aging [ISO]
- angiogenesis [IMP]
- epidermal growth factor receptor signaling pathway [IBA, IDA]
- heart development [IMP]
- insulin receptor signaling pathway [IBA, ISO]
- neuron differentiation [ISO]
- neuron projection development [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of vasoconstriction [ISO]
- regulation of cell proliferation [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
Gene Ontology Cellular Component
SRC
Gene Ontology Biological Process
- bone resorption [IMP]
- branching involved in mammary gland duct morphogenesis [IMP]
- cell migration [IMP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- epidermal growth factor receptor signaling pathway [IBA]
- forebrain development [IGI]
- innate immune response [IBA]
- intracellular signal transduction [IGI]
- negative regulation of extrinsic apoptotic signaling pathway [IBA]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- oogenesis [IMP]
- osteoclast development [IGI]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of podosome assembly [IDA, IGI]
- progesterone receptor signaling pathway [IBA]
- protein phosphorylation [IDA]
- regulation of cell cycle [IBA]
- regulation of cell projection assembly [IGI]
- regulation of cell proliferation [IBA]
- regulation of intracellular estrogen receptor signaling pathway [IMP]
- regulation of protein binding [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- uterus development [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor.
N-Shc (neural Shc) (also ShcC), an adapter protein possessing two phosphotyrosine binding motifs [PTB (phosphotyrosine binding) and SH2 (Src homology 2) domains], is predominantly expressed in mature neurons of the CNS and transmits neurotrophin signals from the TrkB receptor to the Ras/mitogen-activated protein kinase (MAPK) pathway, leading to cellular growth, differentiation, or survival. Here, we demonstrate a novel role of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID