BAIT
NCSTN
9430068N19Rik, AA727311, Aph2, D1Dau13e, Kiaa0253, Nct, mKIAA0253
nicastrin
GO Process (8)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSP90B1
ERp99, GRP94, TA-3, Targ2, Tra-1, Tra1, endoplasmin, gp96
heat shock protein 90, beta (Grp94), member 1
GO Process (6)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum lumen [ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular matrix [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- midbody [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.
Proteolytic processing of amyloid precursor protein generates beta-amyloid (Abeta) peptides that are deposited in senile plaques in brains of aged individuals and patients with Alzheimer's disease. Presenilins (PS1 and PS2) facilitate the final step in Abeta production, the intramembranous gamma-secretase cleavage of amyloid precursor protein. Biochemical and pharmacological evidence support a catalytic or accessory role for PS1 in gamma-secretase cleavage, ... [more]
J. Biol. Chem. May. 24, 2002; 277(21);19236-40 [Pubmed: 11943765]
Throughput
- Low Throughput
Curated By
- BioGRID