CAV1
Gene Ontology Biological Process
- MAPK cascade [IMP]
- T cell costimulation [ISO]
- angiogenesis [IGI]
- apoptotic signaling pathway [ISO]
- calcium ion homeostasis [IMP]
- calcium ion transport [IMP]
- caveola assembly [IMP, ISO]
- caveolin-mediated endocytosis [ISO]
- cellular calcium ion homeostasis [IMP, ISO]
- cellular response to hyperoxia [ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IMP]
- cellular senescence [ISO]
- cholesterol efflux [ISO]
- cholesterol homeostasis [IMP]
- cytosolic calcium ion homeostasis [ISO]
- endocytosis [TAS]
- inactivation of MAPK activity [IMP]
- lactation [IMP]
- lipid storage [IMP]
- maintenance of protein location in cell [ISO]
- mammary gland development [IMP]
- mammary gland involution [IMP]
- membrane depolarization [IMP]
- microtubule polymerization [ISO]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of JAK-STAT cascade [IDA, IGI, IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of anoikis [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cation channel activity [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cytokine-mediated signaling pathway [IMP]
- negative regulation of endothelial cell proliferation [IMP, ISO]
- negative regulation of epithelial cell differentiation [IMP]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of nitric oxide biosynthetic process [IMP]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of peptidyl-tyrosine autophosphorylation [ISO]
- negative regulation of pinocytosis [ISO]
- negative regulation of potassium ion transmembrane transport [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein tyrosine kinase activity [ISO]
- negative regulation of protein ubiquitination [IMP, ISO]
- negative regulation of signal transduction [IDA]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IDA, IMP]
- nitric oxide homeostasis [IMP]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of peptidase activity [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of signal transduction [ISO]
- positive regulation of vasoconstriction [IMP, ISO]
- protein homooligomerization [IDA]
- protein localization [IMP]
- protein oligomerization [IDA]
- receptor internalization involved in canonical Wnt signaling pathway [ISO]
- regulation of blood coagulation [ISO]
- regulation of fatty acid metabolic process [IMP]
- regulation of inward rectifier potassium channel activity [ISO]
- regulation of membrane repolarization during action potential [ISO]
- regulation of peptidase activity [IMP]
- regulation of smooth muscle contraction [IMP]
- regulation of the force of heart contraction [IMP]
- regulation of the force of heart contraction by chemical signal [IGI]
- response to calcium ion [IDA]
- response to estrogen [IDA, ISO]
- response to hypoxia [IMP]
- response to ischemia [IMP]
- response to mechanical stimulus [ISO]
- response to progesterone [ISO]
- skeletal muscle tissue development [IMP]
- triglyceride metabolic process [IMP]
- vasculogenesis [IMP]
- vasoconstriction [IMP]
- vesicle organization [ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- MDM2/MDM4 family protein binding [ISO]
- RNA polymerase I transcription factor binding [ISO]
- SNARE binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- inward rectifier potassium channel inhibitor activity [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- nitric-oxide synthase binding [ISO]
- peptidase activator activity [IMP]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [ISO]
- structural molecule activity [ISO]
- syntaxin binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- RNA polymerase I transcription factor binding [ISO]
- SNARE binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- inward rectifier potassium channel inhibitor activity [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- nitric-oxide synthase binding [ISO]
- peptidase activator activity [IMP]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [ISO]
- structural molecule activity [ISO]
- syntaxin binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Golgi membrane [ISO]
- acrosomal membrane [IDA]
- apical plasma membrane [ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- caveola [IDA, ISO, TAS]
- cell [IMP]
- cell cortex [IDA]
- cell surface [ISO]
- cilium [IDA]
- cytoplasm [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO]
- endosome [ISO]
- focal adhesion [ISO]
- integral component of membrane [IDA]
- integral component of plasma membrane [IDA]
- intracellular [IMP, ISO]
- lipid particle [ISO]
- membrane [IDA]
- membrane raft [IDA, ISO]
- mitochondrion [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- peroxisomal membrane [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IPI, ISO]
NF1
Gene Ontology Biological Process
- MAPK cascade [IMP]
- Ras protein signal transduction [IGI, IMP]
- Schwann cell development [IMP]
- actin cytoskeleton organization [IGI, IMP]
- adrenal gland development [IMP]
- artery morphogenesis [IMP]
- brain development [IMP]
- camera-type eye morphogenesis [IMP]
- cell communication [IMP]
- cerebral cortex development [IMP]
- cognition [ISO]
- collagen fibril organization [IMP]
- extracellular matrix organization [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- forebrain astrocyte development [IMP]
- forebrain morphogenesis [IMP]
- heart development [IMP]
- liver development [IMP]
- metanephros development [IMP]
- myelination in peripheral nervous system [IMP]
- negative regulation of MAP kinase activity [IGI, IMP]
- negative regulation of MAPK cascade [IMP, ISO]
- negative regulation of Rac protein signal transduction [IGI]
- negative regulation of Ras protein signal transduction [IGI, IMP]
- negative regulation of angiogenesis [IGI]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of cell migration [IGI, IMP, ISO]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of cell-matrix adhesion [IGI]
- negative regulation of endothelial cell proliferation [IMP, ISO]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of neuroblast proliferation [IMP]
- negative regulation of neurotransmitter secretion [IGI, IMP]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IGI]
- negative regulation of protein kinase activity [IGI, IMP]
- negative regulation of transcription factor import into nucleus [IMP]
- neural tube development [IGI]
- osteoblast differentiation [IMP]
- peripheral nervous system development [IMP]
- phosphatidylinositol 3-kinase signaling [IMP]
- pigmentation [IGI, IMP]
- positive regulation of Ras GTPase activity [IGI, IMP, ISO]
- positive regulation of adenylate cyclase activity [IMP]
- positive regulation of apoptotic process [IGI, IMP]
- positive regulation of endothelial cell proliferation [IGI]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- positive regulation of neuron apoptotic process [IGI, IMP]
- regulation of Ras GTPase activity [ISO]
- regulation of angiogenesis [IMP, ISO]
- regulation of blood vessel endothelial cell migration [ISO]
- regulation of bone resorption [IMP]
- regulation of cell proliferation [IGI]
- regulation of cell-matrix adhesion [IMP]
- regulation of glial cell differentiation [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of neuron differentiation [ISO]
- regulation of synaptic transmission, GABAergic [IGI]
- response to hypoxia [IMP]
- skeletal muscle tissue development [IMP]
- smooth muscle tissue development [IMP]
- spinal cord development [IMP]
- sympathetic nervous system development [IMP]
- visual learning [IGI, IMP]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt.
Neurofibromin (Nf1) is an approximately 280 kDa protein having tumor suppressor function, presumably by virtue of its GTPase activating domain, but little is known regarding molecular aspects of its effector pathways. Caveolin-1 (Cav-1) regulates diverse signaling molecules and has itself been implicated as a tumor suppressor. Here we demonstrate that Nf1 binds to Cav-1's scaffolding domain and co-immunoprecipitates with Cav-1. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID