ACE
Gene Ontology Biological Process
- angiotensin catabolic process in blood [IC]
- angiotensin maturation [TAS]
- arachidonic acid secretion [IDA]
- blood vessel remodeling [IC]
- cellular protein metabolic process [TAS]
- hematopoietic stem cell differentiation [IC]
- hormone catabolic process [IDA, ISS]
- kidney development [IMP]
- mononuclear cell proliferation [IC]
- peptide catabolic process [IDA]
- regulation of blood pressure [ISS]
- regulation of renal output by angiotensin [IC]
- regulation of smooth muscle cell migration [ISS]
- regulation of systemic arterial blood pressure by renin-angiotensin [IC]
- regulation of vasoconstriction [IC]
- regulation of vasodilation [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BDKRB2
Gene Ontology Biological Process
- arachidonic acid secretion [IDA]
- blood circulation [NAS]
- cell surface receptor signaling pathway [TAS]
- inflammatory response [IC]
- metabolic process [TAS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- regulation of vascular permeability [IC]
- regulation of vasoconstriction [IC]
- smooth muscle contraction [IC]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human ACE and bradykinin B2 receptors form a complex at the plasma membrane.
To investigate how angiotensin I-converting enzyme (ACE) inhibitors enhance the actions of bradykinin (BK) on B2 receptors independent of blocking BK inactivation, we expressed human somatic ACE and B2 receptors in CHO cells. Bradykinin and its ACE-resistant analog were the receptor agonists. B2 fused with green fluorescent protein (GFP) and ACE were coprecipitated with antisera to GFP or ACE shown ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BDKRB2 ACE | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ACE BDKRB2 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID