EPS8
Gene Ontology Biological Process
- Rac protein signal transduction [IDA]
- actin crosslink formation [IDA, IMP]
- actin cytoskeleton reorganization [IMP]
- actin filament bundle assembly [IDA, IGI, IMP]
- actin polymerization-dependent cell motility [IDA]
- adult locomotory behavior [IMP]
- barbed-end actin filament capping [IDA, IMP]
- behavioral response to ethanol [IMP]
- dendritic cell migration [IMP]
- exit from mitosis [IMP]
- regulation of actin filament length [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIN2C
Gene Ontology Biological Process
- cation transmembrane transport [IMP, ISO]
- cation transport [ISO]
- directional locomotion [IGI]
- ion transmembrane transport [IGI]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- negative regulation of protein catabolic process [IGI]
- neuromuscular process controlling balance [IMP]
- protein localization [IGI, IMP]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of membrane potential [IMP]
- response to wounding [IGI]
- startle response [IMP]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.
Dynamic modulation of the actin cytoskeleton is critical for synaptic plasticity, abnormalities of which are thought to contribute to mental illness and addiction. Here we report that mice lacking Eps8, a regulator of actin dynamics, are resistant to some acute intoxicating effects of ethanol and show increased ethanol consumption. In the brain, the N-methyl-D-aspartate (NMDA) receptor is a major target ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID