BAIT
GRIA1
2900051M01Rik, Glr-1, Glr1, GluA1, GluR-A, GluRA, Glur-1, Glur1, HIPA1, gluR-K1, RP23-102H8.1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
GO Process (14)
GO Function (15)
GO Component (26)
Gene Ontology Biological Process
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- long term synaptic depression [IGI]
- long-term memory [IMP, ISO]
- neuronal action potential [ISO]
- positive regulation of membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor internalization [IMP, ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to toxic substance [ISO]
- synaptic transmission [IGI]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function
- G-protein alpha-subunit binding [ISO]
- G-protein beta-subunit binding [ISO]
- PDZ domain binding [ISO]
- adenylate cyclase binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- beta-2 adrenergic receptor binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- myosin V binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- small GTPase binding [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- axonal spine [IDA]
- cell surface [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- dendrite membrane [IDA]
- dendritic shaft [ISO]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [ISO]
- ionotropic glutamate receptor complex [IDA]
- membrane [IDA]
- neuromuscular junction [ISO]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- protein complex [ISO]
- recycling endosome [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
Mus musculus
PREY
GRIN1
GluN1, GluRdelta1, GluRzeta1, M100174, NMD-R1, NMDAR1, NR1, Nmdar, Rgsc174, RP23-132N23.20-010
glutamate receptor, ionotropic, NMDA1 (zeta 1)
GO Process (51)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- associative learning [IMP]
- calcium ion homeostasis [IDA]
- calcium ion transmembrane transport [IGI, ISO]
- calcium ion transport [IDA, IMP]
- cation transport [IGI, ISO]
- cellular calcium ion homeostasis [IMP]
- cerebral cortex development [IMP]
- conditioned taste aversion [IMP]
- ion transmembrane transport [IMP]
- ionotropic glutamate receptor signaling pathway [IDA, IGI, ISO]
- learning [IMP]
- learning or memory [IMP]
- long-term memory [IMP]
- male mating behavior [IMP]
- memory [IMP]
- negative regulation of neuron apoptotic process [IGI, IMP]
- neuromuscular process [IMP]
- olfactory learning [IMP]
- pons maturation [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of cell death [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- prepulse inhibition [IMP]
- propylene metabolic process [IDA]
- protein tetramerization [ISO]
- regulation of axonogenesis [IMP]
- regulation of cell communication [IMP]
- regulation of dendrite morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of ion transmembrane transport [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of neuron apoptotic process [IGI, IMP]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of respiratory gaseous exchange [IMP]
- regulation of synapse assembly [IMP]
- regulation of synaptic plasticity [IMP]
- respiratory gaseous exchange [IMP]
- response to amphetamine [IGI, IMP]
- response to ethanol [ISO]
- response to morphine [IMP]
- rhythmic process [ISO]
- sensory perception of pain [IMP]
- social behavior [IMP]
- startle response [IMP]
- suckling behavior [IMP]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IMP]
- visual learning [IGI, IMP]
Gene Ontology Molecular Function
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- calcium channel activity [IDA, IGI, ISO]
- calcium ion binding [IDA]
- calmodulin binding [IDA]
- cation channel activity [IGI]
- enzyme binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- glycine binding [IMP, ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- cell [IMP]
- cell surface [IDA]
- cytoplasm [IDA]
- dendrite [IDA, ISO]
- dendrite membrane [ISO]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [ISO]
- growth cone [NAS]
- integral component of plasma membrane [ISO]
- membrane [IC, IDA]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- synapse [IDA, ISO]
- synaptic cleft [ISO]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.
Dynamic modulation of the actin cytoskeleton is critical for synaptic plasticity, abnormalities of which are thought to contribute to mental illness and addiction. Here we report that mice lacking Eps8, a regulator of actin dynamics, are resistant to some acute intoxicating effects of ethanol and show increased ethanol consumption. In the brain, the N-methyl-D-aspartate (NMDA) receptor is a major target ... [more]
Cell Oct. 06, 2006; 127(1);213-26 [Pubmed: 17018287]
Throughput
- Low Throughput
Curated By
- BioGRID