CCNC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ERCC3
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [TAS]
- DNA repair [IMP, TAS]
- DNA topological change [IMP]
- apoptotic process [IMP]
- gene expression [TAS]
- hair cell differentiation [IMP]
- nucleotide-excision repair [IMP, TAS]
- nucleotide-excision repair, DNA damage removal [TAS]
- nucleotide-excision repair, DNA duplex unwinding [IMP]
- nucleotide-excision repair, DNA incision [IMP]
- positive regulation of apoptotic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of viral transcription [TAS]
- protein localization [IMP]
- regulation of mitotic cell cycle phase transition [IMP]
- response to UV [IMP]
- response to oxidative stress [IMP]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription-coupled nucleotide-excision repair [IDA, TAS]
- viral process [TAS]
Gene Ontology Molecular Function- 3'-5' DNA helicase activity [IDA, IMP]
- ATPase activity [IDA]
- DNA binding [TAS]
- DNA-dependent ATPase activity [IDA, IMP]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- damaged DNA binding [NAS]
- protein C-terminus binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- transcription factor binding [IDA]
- 3'-5' DNA helicase activity [IDA, IMP]
- ATPase activity [IDA]
- DNA binding [TAS]
- DNA-dependent ATPase activity [IDA, IMP]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- damaged DNA binding [NAS]
- protein C-terminus binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- transcription factor binding [IDA]
Gene Ontology Cellular Component
- holo TFIIH complex [IDA, TAS]
- nucleoplasm [IDA, TAS]
- nucleus [TAS]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
TFIIH is negatively regulated by cdk8-containing mediator complexes.
The mammalian cyclin-dependent kinase 8 (cdk8) gene has been linked with a subset of acute lymphoblastic leukaemias, and its corresponding protein has been functionally implicated in regulation of transcription. Mammalian cdk8 and cyclin C, and their respective yeast homologues, Srb10 and Srb11, are components of the RNA polymerase II holoenzyme complex where they function as a protein kinase that phosphorylates ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID