BAIT

FNBP1

formin binding protein 1
GO Process (1)
GO Function (2)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Rattus norvegicus
PREY

RND2

Arhn, RhoN, Rohn
Rho family GTPase 2
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Rattus norvegicus

Far Western

An interaction is detected between a protein immobilized on a membrane and a purified protein probe.

Publication

Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching.

Kakimoto T, Katoh H, Negishi M

Rho family GTPases regulate neuronal morphology. Rnd subfamily is a new branch of Rho family GTPases. Of these GTPases, Rnd2 is specifically expressed in brain. We recently identified Rapostlin as a novel effector of Rnd2. Rapostlin induces neurite branching in response to Rnd2 in PC12 cells. During the cloning of Rapostlin, we have found two mainly expressed splicing variants of ... [more]

J. Biol. Chem. Apr. 02, 2004; 279(14);14104-10 [Pubmed: 14732713]

Throughput

  • Low Throughput

Additional Notes

  • All isoforms of FNBP1 bind Rnd2 in vitro
  • Isoforms (Uniprot IDs): Q8R511-2, Q8R511-3, Q8R511-4, Q8R511-5, Q8R511-6, Q8R511-7 interacts with Q5HZE6

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
FNBP1 RND2
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Low-BioGRID
869759

Curated By

  • BioGRID