BAIT
HSPA1A
HEL-S-103, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1, DAQB-147D11.1
heat shock 70kDa protein 1A
GO Process (20)
GO Function (13)
GO Component (17)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- cellular heat acclimation [IMP]
- cellular response to heat [IDA]
- cellular response to oxidative stress [TAS]
- gene expression [TAS]
- mRNA catabolic process [IDA]
- mRNA metabolic process [TAS]
- negative regulation of apoptotic process [IMP, TAS]
- negative regulation of cell death [IDA, IMP]
- negative regulation of cell growth [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of inclusion body assembly [IDA]
- negative regulation of protein ubiquitination [IDA]
- positive regulation of erythrocyte differentiation [IMP]
- protein refolding [IDA]
- protein stabilization [TAS]
- regulation of cell death [IMP]
- response to unfolded protein [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [IDA]
- G-protein coupled receptor binding [IPI]
- double-stranded RNA binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA, NAS, TAS]
- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [IDA]
- G-protein coupled receptor binding [IPI]
- double-stranded RNA binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA, NAS, TAS]
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- aggresome [IDA]
- blood microparticle [IDA]
- centriole [IDA]
- cytoplasm [IDA, TAS]
- cytosol [IDA, TAS]
- endoplasmic reticulum [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- inclusion body [IDA]
- mitochondrion [TAS]
- nuclear speck [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- ribonucleoprotein complex [IDA]
- ubiquitin ligase complex [IDA]
- vesicle [IDA]
Homo sapiens
PREY
HMGA1
HMG-R, HMGA1A, HMGIY, RP11-513I15.2
high mobility group AT-hook 1
GO Process (16)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA unwinding involved in DNA replication [NAS]
- base-excision repair [IDA]
- establishment of integrated proviral latency [TAS]
- negative regulation of cell proliferation [IMP]
- negative regulation of chromatin silencing [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- nucleosome disassembly [TAS]
- oncogene-induced cell senescence [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- protein complex assembly [TAS]
- regulation of transcription, DNA-templated [TAS]
- response to virus [IEP]
- senescence-associated heterochromatin focus assembly [IDA]
- viral process [TAS]
Gene Ontology Molecular Function- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [TAS]
- DNA binding [TAS]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- peroxisome proliferator activated receptor binding [IDA]
- protein binding [IPI]
- retinoic acid receptor binding [IDA]
- retinoid X receptor binding [IDA]
- transcription factor binding [IDA]
- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [TAS]
- DNA binding [TAS]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- peroxisome proliferator activated receptor binding [IDA]
- protein binding [IPI]
- retinoic acid receptor binding [IDA]
- retinoid X receptor binding [IDA]
- transcription factor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
Interaction proteomics of the HMGA chromatin architectural factors.
The high mobility group A (HMGA) chromatin architectural transcription factors are a group of proteins involved in development and neoplastic transformation. They take part in an articulated interaction network, both with DNA and other nuclear proteins, organizing multimolecular complexes at chromatin level. Here, we report the development of a novel in vitro strategy for the identification of HMGA molecular partners ... [more]
Proteomics Nov. 01, 2008; 8(22);4721-32 [Pubmed: 18850631]
Throughput
- Low Throughput
Additional Notes
- figure 5, table 1. interaction partners identified by 2D BOL (blot overlay) and nano-LC-ESI-MS/MS.
Curated By
- BioGRID