BAIT
CALM1
CALML2, CAMI, CPVT4, DD132, PHKD, caM
calmodulin 1 (phosphorylase kinase, delta)
GO Process (43)
GO Function (11)
GO Component (13)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- detection of calcium ion [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glucose metabolic process [TAS]
- glycogen catabolic process [TAS]
- innate immune response [TAS]
- inositol phosphate metabolic process [TAS]
- membrane organization [TAS]
- muscle contraction [TAS]
- negative regulation of peptidyl-threonine phosphorylation [TAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- nitric oxide metabolic process [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cyclic nucleotide metabolic process [IDA]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [IDA]
- positive regulation of peptidyl-threonine phosphorylation [TAS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of protein autophosphorylation [TAS]
- positive regulation of protein dephosphorylation [IDA]
- positive regulation of protein serine/threonine kinase activity [TAS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of cytokinesis [IMP]
- regulation of heart rate [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to calcium ion [IDA]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- substantia nigra development [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [IPI]
- calcium ion binding [IDA, ISS]
- ion channel binding [IPI]
- phospholipase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase activator activity [IDA]
- protein serine/threonine kinase activator activity [TAS]
- thioesterase binding [IPI]
- titin binding [IPI]
- N-terminal myristoylation domain binding [IPI]
- calcium ion binding [IDA, ISS]
- ion channel binding [IPI]
- phospholipase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase activator activity [IDA]
- protein serine/threonine kinase activator activity [TAS]
- thioesterase binding [IPI]
- titin binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
SIRT2
5730427M03Rik, SIR2L2, Sir2l
sirtuin 2
GO Process (46)
GO Function (14)
GO Component (23)
Gene Ontology Biological Process
- cellular lipid catabolic process [IMP]
- cellular response to caloric restriction [IDA]
- cellular response to epinephrine stimulus [IDA]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to hypoxia [ISO]
- cellular response to molecule of bacterial origin [ISO]
- cellular response to oxidative stress [IDA]
- hepatocyte growth factor receptor signaling pathway [ISO]
- histone H3 deacetylation [IMP, ISO]
- histone H4 deacetylation [IMP, ISO]
- histone deacetylation [IGI]
- myelination in peripheral nervous system [IMP, ISO]
- negative regulation of NLRP3 inflammasome complex assembly [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of autophagy [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of defense response to bacterium [IMP, ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of oligodendrocyte differentiation [ISO]
- negative regulation of oligodendrocyte progenitor proliferation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [IMP]
- negative regulation of protein catabolic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of striated muscle tissue development [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- peptidyl-lysine deacetylation [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of DNA binding [IDA]
- positive regulation of attachment of spindle microtubules to kinetochore [IMP]
- positive regulation of cell division [IMP]
- positive regulation of execution phase of apoptosis [IMP]
- positive regulation of meiosis [IMP]
- positive regulation of oocyte maturation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein deacetylation [IDA, IMP, ISO]
- protein kinase B signaling [ISO]
- regulation of cell cycle [ISO]
- regulation of fat cell differentiation [IMP]
- regulation of myelination [IMP, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
- tubulin deacetylation [IGI, IMP, ISO]
Gene Ontology Molecular Function- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO]
- NAD-dependent protein deacetylase activity [ISO]
- beta-tubulin binding [IDA]
- chromatin binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [IMP, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- tubulin deacetylase activity [IMP, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO]
- NAD-dependent protein deacetylase activity [ISO]
- beta-tubulin binding [IDA]
- chromatin binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [IMP, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- tubulin deacetylase activity [IMP, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA, ISO]
- centriole [ISO]
- centrosome [ISO]
- chromosome [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- glial cell projection [ISO]
- juxtaparanode region of axon [ISO]
- lateral loop [ISO]
- meiotic spindle [IDA]
- microtubule [ISO]
- midbody [IDA, ISO]
- mitotic spindle [ISO]
- myelin sheath [IDA, ISO]
- myelin sheath abaxonal region [ISO]
- nuclear heterochromatin [ISO]
- nucleus [IDA, ISO]
- paranodal junction [IDA, ISO]
- paranode region of axon [ISO]
- perikaryon [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- spindle [ISO]
- terminal loop [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.
Calmodulin is an essential Ca2+-binding protein that binds to a variety of targets that carry out critical signaling functions. We describe the proteomic characterization of mouse brain Ca2+-calmodulin-binding proteins that were purified using calmodulin affinity chromatography. Proteins in the eluates from four different affinity chromatography experiments were identified by 1-DE and in-gel digestion followed by LC-MS/MS. Parallel experiments were performed ... [more]
J. Proteome Res. Mar. 01, 2006; 5(3);669-87 [Pubmed: 16512683]
Throughput
- High Throughput
Curated By
- BioGRID