BAIT
CALM1
CALML2, CAMI, CPVT4, DD132, PHKD, caM
calmodulin 1 (phosphorylase kinase, delta)
GO Process (43)
GO Function (11)
GO Component (13)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- detection of calcium ion [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glucose metabolic process [TAS]
- glycogen catabolic process [TAS]
- innate immune response [TAS]
- inositol phosphate metabolic process [TAS]
- membrane organization [TAS]
- muscle contraction [TAS]
- negative regulation of peptidyl-threonine phosphorylation [TAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- nitric oxide metabolic process [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cyclic nucleotide metabolic process [IDA]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [IDA]
- positive regulation of peptidyl-threonine phosphorylation [TAS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of protein autophosphorylation [TAS]
- positive regulation of protein dephosphorylation [IDA]
- positive regulation of protein serine/threonine kinase activity [TAS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of cytokinesis [IMP]
- regulation of heart rate [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to calcium ion [IDA]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- substantia nigra development [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [IPI]
- calcium ion binding [IDA, ISS]
- ion channel binding [IPI]
- phospholipase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase activator activity [IDA]
- protein serine/threonine kinase activator activity [TAS]
- thioesterase binding [IPI]
- titin binding [IPI]
- N-terminal myristoylation domain binding [IPI]
- calcium ion binding [IDA, ISS]
- ion channel binding [IPI]
- phospholipase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase activator activity [IDA]
- protein serine/threonine kinase activator activity [TAS]
- thioesterase binding [IPI]
- titin binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP3CB
1110063J16Rik, Calnb, CnAbeta, Cnab
protein phosphatase 3, catalytic subunit, beta isoform
GO Process (19)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- T cell differentiation [IMP]
- T cell homeostasis [IMP]
- calcineurin-NFAT signaling cascade [ISO]
- calcium ion-dependent exocytosis [IDA]
- cellular response to drug [ISO]
- dephosphorylation [IDA]
- heart development [IMP]
- locomotion involved in locomotory behavior [IMP]
- lymphangiogenesis [IGI]
- negative regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IMP, ISO]
- protein phosphorylation [IMP]
- regulation of gene expression [IMP]
- regulation of insulin secretion [ISO]
- response to cytokine [IMP]
- response to stress [IMP]
Gene Ontology Molecular Function- calcium ion binding [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [IMP]
- drug binding [ISO]
- enzyme binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein phosphatase 2B binding [ISO]
- protein serine/threonine phosphatase activity [IDA]
- calcium ion binding [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [IMP]
- drug binding [ISO]
- enzyme binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein phosphatase 2B binding [ISO]
- protein serine/threonine phosphatase activity [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.
Calmodulin is an essential Ca2+-binding protein that binds to a variety of targets that carry out critical signaling functions. We describe the proteomic characterization of mouse brain Ca2+-calmodulin-binding proteins that were purified using calmodulin affinity chromatography. Proteins in the eluates from four different affinity chromatography experiments were identified by 1-DE and in-gel digestion followed by LC-MS/MS. Parallel experiments were performed ... [more]
J. Proteome Res. Mar. 01, 2006; 5(3);669-87 [Pubmed: 16512683]
Throughput
- High Throughput
Curated By
- BioGRID