BAIT
CALM1
CALML2, CAMI, CPVT4, DD132, PHKD, caM
calmodulin 1 (phosphorylase kinase, delta)
GO Process (43)
GO Function (11)
GO Component (13)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- detection of calcium ion [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glucose metabolic process [TAS]
- glycogen catabolic process [TAS]
- innate immune response [TAS]
- inositol phosphate metabolic process [TAS]
- membrane organization [TAS]
- muscle contraction [TAS]
- negative regulation of peptidyl-threonine phosphorylation [TAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- nitric oxide metabolic process [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cyclic nucleotide metabolic process [IDA]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [IDA]
- positive regulation of peptidyl-threonine phosphorylation [TAS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of protein autophosphorylation [TAS]
- positive regulation of protein dephosphorylation [IDA]
- positive regulation of protein serine/threonine kinase activity [TAS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of cytokinesis [IMP]
- regulation of heart rate [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to calcium ion [IDA]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- substantia nigra development [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [IPI]
- calcium ion binding [IDA, ISS]
- ion channel binding [IPI]
- phospholipase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase activator activity [IDA]
- protein serine/threonine kinase activator activity [TAS]
- thioesterase binding [IPI]
- titin binding [IPI]
- N-terminal myristoylation domain binding [IPI]
- calcium ion binding [IDA, ISS]
- ion channel binding [IPI]
- phospholipase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase activator activity [IDA]
- protein serine/threonine kinase activator activity [TAS]
- thioesterase binding [IPI]
- titin binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
NF1
AW494271, E030030H24Rik, Nf-1, RP23-188A3.1
neurofibromatosis 1
GO Process (66)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- Ras protein signal transduction [IGI, IMP]
- Schwann cell development [IMP]
- actin cytoskeleton organization [IGI, IMP]
- adrenal gland development [IMP]
- artery morphogenesis [IMP]
- brain development [IMP]
- camera-type eye morphogenesis [IMP]
- cell communication [IMP]
- cerebral cortex development [IMP]
- cognition [ISO]
- collagen fibril organization [IMP]
- extracellular matrix organization [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- forebrain astrocyte development [IMP]
- forebrain morphogenesis [IMP]
- heart development [IMP]
- liver development [IMP]
- metanephros development [IMP]
- myelination in peripheral nervous system [IMP]
- negative regulation of MAP kinase activity [IGI, IMP]
- negative regulation of MAPK cascade [IMP, ISO]
- negative regulation of Rac protein signal transduction [IGI]
- negative regulation of Ras protein signal transduction [IGI, IMP]
- negative regulation of angiogenesis [IGI]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of cell migration [IGI, IMP, ISO]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of cell-matrix adhesion [IGI]
- negative regulation of endothelial cell proliferation [IMP, ISO]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of neuroblast proliferation [IMP]
- negative regulation of neurotransmitter secretion [IGI, IMP]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IGI]
- negative regulation of protein kinase activity [IGI, IMP]
- negative regulation of transcription factor import into nucleus [IMP]
- neural tube development [IGI]
- osteoblast differentiation [IMP]
- peripheral nervous system development [IMP]
- phosphatidylinositol 3-kinase signaling [IMP]
- pigmentation [IGI, IMP]
- positive regulation of Ras GTPase activity [IGI, IMP, ISO]
- positive regulation of adenylate cyclase activity [IMP]
- positive regulation of apoptotic process [IGI, IMP]
- positive regulation of endothelial cell proliferation [IGI]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- positive regulation of neuron apoptotic process [IGI, IMP]
- regulation of Ras GTPase activity [ISO]
- regulation of angiogenesis [IMP, ISO]
- regulation of blood vessel endothelial cell migration [ISO]
- regulation of bone resorption [IMP]
- regulation of cell proliferation [IGI]
- regulation of cell-matrix adhesion [IMP]
- regulation of glial cell differentiation [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of neuron differentiation [ISO]
- regulation of synaptic transmission, GABAergic [IGI]
- response to hypoxia [IMP]
- skeletal muscle tissue development [IMP]
- smooth muscle tissue development [IMP]
- spinal cord development [IMP]
- sympathetic nervous system development [IMP]
- visual learning [IGI, IMP]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.
Calmodulin is an essential Ca2+-binding protein that binds to a variety of targets that carry out critical signaling functions. We describe the proteomic characterization of mouse brain Ca2+-calmodulin-binding proteins that were purified using calmodulin affinity chromatography. Proteins in the eluates from four different affinity chromatography experiments were identified by 1-DE and in-gel digestion followed by LC-MS/MS. Parallel experiments were performed ... [more]
J. Proteome Res. Mar. 01, 2006; 5(3);669-87 [Pubmed: 16512683]
Throughput
- High Throughput
Curated By
- BioGRID