An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Involvement of protein kinase PKN1 in G2/M delay caused by arsenite.

Isagawa T, Takahashi M, Kato T, Mukai H, Ono Y

PKN1 is a serine/threonine protein kinase that has been reported to mediate cellular response to stress. We show here that in response to arsenite exposure, PKN1 kinase activity was stimulated, which was associated with increased binding of PKN1 to Cdc25C and delayed mitotic entry. A role for PKN1 in mediating arsenite-induced G(2)/M delay was supported by the finding that expression ... [more]

Mol. Carcinog. May. 01, 2005; 43(1);1-12 [Pubmed: 15791647]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PKN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

MBP