BAIT
ADF1
cof1, SPAC20G4.06c
actin depolymerizing factor, cofilin
GO Process (2)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
END4
sla2, SPAC688.11
Huntingtin-interacting protein homolog
GO Process (10)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G1 to G0 transition [IMP]
- actin cytoskeleton organization [IMP]
- activation of bipolar cell growth [IMP]
- cellular protein localization [IMP]
- cellular response to nitrogen starvation [IMP]
- cortical actin cytoskeleton organization [IMP]
- endocytosis [IMP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- fungal-type cell wall organization or biogenesis [IMP]
- plasma membrane raft distribution [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Actin Filament Severing by Cofilin Dismantles Actin Patches and Produces Mother Filaments for New Patches.
BACKGROUND: Yeast cells depend on Arp2/3 complex to assemble actin filaments at sites of endocytosis, but the source of the initial filaments required to activate Arp2/3 complex is not known. RESULTS: We tested the proposal that cofilin severs actin filaments during endocytosis in fission yeast cells using a mutant cofilin defective in severing. We used quantitative fluorescence microscopy to track ... [more]
Curr. Biol. May. 29, 2013; 0(0); [Pubmed: 23727096]
Throughput
- Low Throughput
Ontology Terms
- vegetative growth (APO:0000106)
Additional Notes
- end4-delta858-1102 adf1-M2 double mutant
Curated By
- BioGRID