BAIT
LMNA
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, RP11-54H19.1
lamin A/C
GO Process (14)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [ISS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle organ development [IMP]
- positive regulation of cell aging [IDA]
- protein localization to nucleus [ISS]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HCFC1
CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF
host cell factor C1
GO Process (12)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- chromatin organization [TAS]
- histone H4-K16 acetylation [IDA]
- histone H4-K5 acetylation [IDA]
- histone H4-K8 acetylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of cell cycle [TAS]
- positive regulation of gene expression [IDA]
- protein stabilization [IDA]
- regulation of protein complex assembly [IDA]
- regulation of transcription, DNA-templated [IDA]
- release from viral latency [NAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- chromatin binding [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription coactivator activity [IMP]
- chromatin binding [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription coactivator activity [IMP]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.
We have developed a new technique for proximity-dependent labeling of proteins in eukaryotic cells. Named BioID for proximity-dependent biotin identification, this approach is based on fusion of a promiscuous Escherichia coli biotin protein ligase to a targeting protein. BioID features proximity-dependent biotinylation of proteins that are near-neighbors of the fusion protein. Biotinylated proteins may be isolated by affinity capture and ... [more]
J. Cell Biol. Mar. 19, 2012; 196(6);801-10 [Pubmed: 22412018]
Throughput
- High Throughput
Curated By
- BioGRID