HDAC3
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- cellular response to fluid shear stress [IDA]
- chromatin modification [TAS]
- negative regulation of JNK cascade [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell cycle [TAS]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of TOR signaling [IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein deacetylation [IDA]
- regulation of protein stability [IDA]
- small molecule metabolic process [TAS]
- spindle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCT3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The functional interactome landscape of the human histone deacetylase family.
Histone deacetylases (HDACs) are a diverse family of essential transcriptional regulatory enzymes, that function through the spatial and temporal recruitment of protein complexes. As the composition and regulation of HDAC complexes are only partially characterized, we built the first global protein interaction network for all 11 human HDACs in T cells. Integrating fluorescence microscopy, immunoaffinity purifications, quantitative mass spectrometry, and ... [more]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Prey proteins with a SAINT score of >= 0.90 in HDAC1 and HDAC2, >= and 0.75 in HDAC3-10 were considered putative protein interactions, while prey proteins with SAINT scores of > 0.95 in both HDAC11 biological replicates were considered as putative interactions.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CCT3 HDAC3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9238 | BioGRID | 2255918 | |
| CCT3 HDAC3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8549 | BioGRID | 3134212 |
Curated By
- BioGRID