BAIT
HDAC11
HD11
histone deacetylase 11
GO Process (2)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNTTIP2
ERBP, FCF2, HSU15552, LPTS-RP2, TdIF2
deoxynucleotidyltransferase, terminal, interacting protein 2
GO Process (0)
GO Function (1)
GO Component (2)
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The functional interactome landscape of the human histone deacetylase family.
Histone deacetylases (HDACs) are a diverse family of essential transcriptional regulatory enzymes, that function through the spatial and temporal recruitment of protein complexes. As the composition and regulation of HDAC complexes are only partially characterized, we built the first global protein interaction network for all 11 human HDACs in T cells. Integrating fluorescence microscopy, immunoaffinity purifications, quantitative mass spectrometry, and ... [more]
Mol. Syst. Biol. Jun. 11, 2013; 9(0);672 [Pubmed: 23752268]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- cell line: ccrf-cem cell (BTO:0000736) [acute t cell leukemia (DOID:5603)]
Additional Notes
- Exogenous expression of bait
- Prey proteins with a SAINT score of >= 0.90 in HDAC1 and HDAC2, >= and 0.75 in HDAC3-10 were considered putative protein interactions, while prey proteins with SAINT scores of > 0.95 in both HDAC11 biological replicates were considered as putative interactions.
Curated By
- BioGRID