HDAC6
Gene Ontology Biological Process
- Hsp90 deacetylation [IMP]
- aggresome assembly [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to topologically incorrect protein [IMP]
- histone deacetylation [IDA, ISS]
- intracellular protein transport [IMP]
- lysosome localization [IMP]
- macroautophagy [IMP]
- misfolded or incompletely synthesized protein catabolic process [IMP]
- negative regulation of hydrogen peroxide metabolic process [IC]
- negative regulation of oxidoreductase activity [IC]
- negative regulation of protein complex disassembly [IMP]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- peptidyl-lysine deacetylation [IMP]
- polyubiquitinated misfolded protein transport [IMP]
- positive regulation of chaperone-mediated protein complex assembly [IMP]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of hydrogen peroxide-mediated programmed cell death [IDA]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of signal transduction [IMP]
- protein deacetylation [IMP]
- regulation of androgen receptor signaling pathway [TAS]
- regulation of gene expression, epigenetic [IMP]
- regulation of microtubule-based movement [IC]
- regulation of receptor activity [IMP]
- response to growth factor [IMP]
- response to misfolded protein [IMP]
- response to organic substance [IMP]
- response to toxic substance [IMP]
- tubulin deacetylation [IDA, ISS]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- alpha-tubulin binding [IDA]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- dynein complex binding [IDA]
- enzyme binding [ISS]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- microtubule binding [IDA, ISS]
- polyubiquitin binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- tubulin deacetylase activity [IDA, ISS]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- alpha-tubulin binding [IDA]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- dynein complex binding [IDA]
- enzyme binding [ISS]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- microtubule binding [IDA, ISS]
- polyubiquitin binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- tubulin deacetylase activity [IDA, ISS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- aggresome [IDA]
- axon [ISS]
- caveola [IDA]
- cell leading edge [IDA]
- cytoplasm [ISS]
- cytosol [ISS]
- dendrite [ISS]
- dynein complex [IDA]
- histone deacetylase complex [IDA]
- inclusion body [IDA]
- microtubule [IDA]
- microtubule associated complex [IDA]
- nucleoplasm [IDA]
- nucleus [ISS]
- perikaryon [ISS]
- perinuclear region of cytoplasm [IDA]
TUBA1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors.
Histone deacetylase (HDAC) is an emergent anticancer target, and HR23B is a biomarker for response to HDAC inhibitors. We show here that HR23B has impacts on two documented effects of HDAC inhibitors; HDAC inhibitors cause apoptosis in cells expressing high levels of HR23B, whereas in cells with low level expression, HDAC inhibitor treatment is frequently associated with autophagy. The mechanism ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC6 TUBA1B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| TUBA1B HDAC6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HDAC6 TUBA1B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HDAC6 TUBA1B | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2208722 |
Curated By
- BioGRID