BAIT
NEDD4
AA959633, AL023035, AU019897, E430025J12Rik, Nedd4-1, Nedd4a, mKIAA0093
neural precursor cell expressed, developmentally down-regulated 4
GO Process (16)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GRIN2D
GluN2D
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GO Process (11)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- cation transmembrane transport [IDA]
- cation transport [IDA]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, IMP, ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of sensory perception of pain [ISO]
- startle response [ISO]
- synaptic transmission, glutamatergic [IMP]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- cation channel activity [IDA]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IMP]
- ionotropic glutamate receptor activity [IDA]
- neurotransmitter binding [IMP]
- protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- cation channel activity [IDA]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IMP]
- ionotropic glutamate receptor activity [IDA]
- neurotransmitter binding [IMP]
- protein binding [IPI]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D.
NMDA receptors are a family of glutamate-gated ion channels that regulate various CNS functions such as synaptic plasticity and learning. However hypo- or hyper-activation of NMDA receptors is critically involved in many neurological and psychiatric conditions such as pain, stroke, epilepsy, neurodegeneration, schizophrenia, and depression. Thus, it is important to identify mechanisms (such as by targeted ubiquitination) that regulate the levels ... [more]
Neuropharmacology Apr. 29, 2013; 0(0); [Pubmed: 23639431]
Throughput
- Low Throughput
Curated By
- BioGRID