CAMK1
Gene Ontology Biological Process
- positive regulation of dendritic spine development [IMP]
- positive regulation of muscle cell differentiation [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of synapse structural plasticity [IMP]
- protein phosphorylation [IDA]
- regulation of muscle cell differentiation [IDA]
- regulation of protein binding [IDA]
- regulation of protein localization [IDA]
Gene Ontology Molecular Function
CDK4
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- mitotic cell cycle [TAS]
- negative regulation of cell cycle arrest [IDA]
- positive regulation of G2/M transition of mitotic cell cycle [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of fibroblast proliferation [IMP]
- protein phosphorylation [IDA]
- regulation of gene expression [IMP]
- response to drug [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.
Cell cycle progression through its regulatory control by changes in intracellular Ca(2+) levels at the G1/S transition mediates cellular proliferation and viability. Ca(2+)/CaM-dependent kinase 1 (CaMKI) appears critical in regulating the assembly of the cyclin D1/cdk4 complex essential for G1 progression, but how this occurs is unknown. Cyclin D1/cdk4 assembly in the early G1 phase is also regulated via binding ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID