BAIT

FBXW4

DAC, FBW4, FBWD4, SHFM3, SHSF3, RP11-529I10.3
F-box and WD repeat domain containing 4
UPS Project
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

SKIV2L

170A, DDX13, HLP, SKI2, SKI2W, SKIV2, THES2, DADB-112B14.3
superkiller viralicidic activity 2-like (S. cerevisiae)
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers.

Lockwood WW, Chandel SK, Stewart GL, Erdjument-Bromage H, Beverly LJ

Identification of novel proteins that can potentially contribute to carcinogenesis is a requisite venture. Herein, we report the first biochemical characterization of the novel F-box and WD40 containing protein, FBXW4. We have identified interacting protein partners and demonstrated that FBXW4 is part of a ubiquitin ligase complex. Furthermore, the Fbxw4 locus is a common site of proviral insertion in a ... [more]

PLoS ONE May. 10, 2013; 8(5);e63610 [Pubmed: 23658844]

Throughput

  • High Throughput

Curated By

  • BioGRID