BCL2A1A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PMAIP1
Gene Ontology Biological Process
- T cell homeostasis [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic process [ISO]
- cellular response to DNA damage stimulus [IMP]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of mitochondrial membrane potential [IDA]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [IMP]
- release of cytochrome c from mitochondria [IDA, IMP]
- response to UV [IMP]
- response to X-ray [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1.
Noxa is a member of the pro-apoptotic BH3-only group of Bcl-2 proteins that is known to bind specifically to anti-apoptotic Mcl-1 and A1, antagonizing their function. Mcl-1 has been reported to have a short half-life, and Noxa up-regulation accelerates Mcl-1 degradation by the proteasome. Unlike human Noxa, mouse Noxa has two BH3-domains, which both have affinity for Mcl-1. We here ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID