VCP
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- ER to Golgi vesicle-mediated transport [ISO]
- ER-associated ubiquitin-dependent protein catabolic process [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- aggresome assembly [IGI]
- cellular response to DNA damage stimulus [ISO]
- double-strand break repair [ISO]
- positive regulation of Lys63-specific deubiquitinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein K63-linked deubiquitination [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein N-linked glycosylation via asparagine [ISO]
- protein hexamerization [ISO]
- protein homooligomerization [ISO]
- protein ubiquitination [ISO]
- retrograde protein transport, ER to cytosol [ISO]
- translesion synthesis [ISO]
- ubiquitin-dependent protein catabolic process [IGI]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- deubiquitinase activator activity [ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- ubiquitin-specific protease binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- deubiquitinase activator activity [ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [ISO]
- lipid particle [ISO]
- myelin sheath [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- proteasome complex [ISO]
- protein complex [IPI]
- site of double-strand break [ISO]
PRKDC
Gene Ontology Biological Process
- B cell lineage commitment [IMP]
- T cell differentiation in thymus [IMP]
- T cell lineage commitment [IMP]
- T cell receptor V(D)J recombination [IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cellular response to insulin stimulus [ISO]
- double-strand break repair [IMP]
- double-strand break repair via homologous recombination [IBA]
- double-strand break repair via nonhomologous end joining [IMP]
- ectopic germ cell programmed cell death [IMP]
- heart development [IGI]
- immunoglobulin V(D)J recombination [IMP]
- immunoglobulin production [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- lymphocyte differentiation [IMP]
- negative regulation of cellular senescence [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of response to gamma radiation [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [IBA]
- positive regulation of apoptotic process [IMP]
- positive regulation of developmental growth [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of immune system process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- pro-B cell differentiation [IMP]
- protein destabilization [IDA]
- protein phosphorylation [IDA]
- regulation of circadian rhythm [IMP]
- response to gamma radiation [IMP]
- signal transduction involved in mitotic G1 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
- spleen development [ISO]
- telomere maintenance [IMP]
- thymus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein degradation, is phosphorylated by DNA-PK and recruited to DNA double-strand break sites to regulate DNA damage repair. However, it is not clear whether VCP is involved in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKDC VCP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID