BAIT
BAI1
GDAIF
brain-specific angiogenesis inhibitor 1
GO Process (5)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
MAGI2
ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM
membrane associated guanylate kinase, WW and PDZ domain containing 2
GO Process (16)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein signal transduction [ISS]
- cellular response to nerve growth factor stimulus [ISS]
- cytoplasmic transport [ISS]
- glomerular visceral epithelial cell development [ISS]
- mitotic cell cycle arrest [ISS]
- negative regulation of activin receptor signaling pathway [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of protein kinase B signaling [IDA]
- nerve growth factor signaling pathway [ISS]
- planar cell polarity pathway involved in axis elongation [NAS]
- positive regulation of neuron projection development [ISS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of receptor internalization [IDA]
- protein heterooligomerization [ISS]
- receptor clustering [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Brain-Specific Angiogenesis Inhibitor-1 Signaling, Regulation and Enrichment in the Postsynaptic Density.
Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor (GPCR) that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties. We found that over-expression of BAI1 results in activation of the Rho pathway via a Galpha12/13-dependent mechanism, with truncation of the BAI1 N-terminus (NT) resulting in a dramatic enhancement in receptor signaling. This constitutive activity of the truncated ... [more]
J. Biol. Chem. Jun. 19, 2013; 0(0); [Pubmed: 23782696]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MAGI2 BAI1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID