BAIT

BAI1

GDAIF
brain-specific angiogenesis inhibitor 1
Homo sapiens
PREY

MAGI3

MAGI-3, dJ730K3.2, RP4-730K3.1
membrane associated guanylate kinase, WW and PDZ domain containing 3
GO Process (3)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

Brain-Specific Angiogenesis Inhibitor-1 Signaling, Regulation and Enrichment in the Postsynaptic Density.

Stephenson JR, Paavola KJ, Schaefer SA, Kaur B, Van Meir EG, Hall RA

Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor (GPCR) that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties. We found that over-expression of BAI1 results in activation of the Rho pathway via a Galpha12/13-dependent mechanism, with truncation of the BAI1 N-terminus (NT) resulting in a dramatic enhancement in receptor signaling. This constitutive activity of the truncated ... [more]

J. Biol. Chem. Jun. 19, 2013; 0(0); [Pubmed: 23782696]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MAGI3 BAI1
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Low-BioGRID
-

Curated By

  • BioGRID