BCL10
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IDA, TAS]
- adaptive immune response [TAS]
- cell death [IDA]
- cellular response to mechanical stimulus [IEP]
- innate immune response [IEP, TAS]
- interleukin-6 biosynthetic process [NAS]
- lymphotoxin A biosynthetic process [NAS]
- negative regulation of mature B cell apoptotic process [IDA]
- neural tube closure [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IDA]
- positive regulation of interleukin-8 biosynthetic process [IMP]
- positive regulation of mast cell cytokine production [NAS]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein homooligomerization [ISS, TAS]
- protein oligomerization [IPI]
- response to food [IDA]
- response to molecule of bacterial origin [IEP]
- toll-like receptor signaling pathway [IC]
Gene Ontology Molecular Function- NF-kappaB binding [IDA]
- enzyme binding [IPI]
- kinase activator activity [IDA]
- kinase binding [IPI]
- protease binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IDA]
- protein self-association [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [IPI]
- NF-kappaB binding [IDA]
- enzyme binding [IPI]
- kinase activator activity [IDA]
- kinase binding [IPI]
- protease binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IDA]
- protein self-association [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
USP9X
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- axon extension [IMP]
- female gamete generation [TAS]
- gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- neuron migration [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of proteasomal protein catabolic process [IBA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IMP, TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex.
The ubiquitin conjugation system plays an important role in immune regulation; however, the ubiquitin-specific proteases (USPs) that carry out deubiquitination of cellular substrates are poorly understood. Here we show that in vivo knockdown of the deubiquitinating enzyme USP9X attenuates T-cell proliferation. In addition, naive CD4(+) T cells from USP9X knockdown chimeric mice display decreased cytokine production and T helper cell ... [more]
Throughput
- Low Throughput
Additional Notes
- CD3 + anti-CD28
- JE6.1 cells were stimulated with anti-
Curated By
- BioGRID