PAK2
Gene Ontology Biological Process
- intracellular signal transduction [IBA]
- mitotic cell cycle [IBA]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of apoptotic process [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IBA, ISO]
- nucleoplasm [ISO]
PAK2
Gene Ontology Biological Process
- intracellular signal transduction [IBA]
- mitotic cell cycle [IBA]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of apoptotic process [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IBA, ISO]
- nucleoplasm [ISO]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets.
The brain-enriched p21cdc42/rac1-activated serine/threonine kinase, p65PAK, was identified and purified on the basis of overlays with [gamma-32P]GTP-Cdc42 onto SDS-fractionated proteins (Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., and Lim, L. (1994) Nature 367, 40-46). In this study, the ubiquitously expressed p21cdc42/rac1 binding protein with relative molecular weight of 62,000 was purified from rat testes and shown to contain peptides ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID