PAK2
Gene Ontology Biological Process
- intracellular signal transduction [IBA]
- mitotic cell cycle [IBA]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of apoptotic process [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IBA, ISO]
- nucleoplasm [ISO]
CDC42
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- Golgi organization [IMP]
- actin cytoskeleton organization [ISO]
- actin filament branching [IMP]
- actin filament bundle assembly [ISO]
- actin filament organization [IMP]
- adherens junction organization [ISO]
- canonical Wnt signaling pathway [ISO]
- cardiac conduction system development [ISO]
- cellular protein localization [ISO]
- dendritic cell migration [ISO]
- epidermis morphogenesis [ISO]
- epithelial cell-cell adhesion [ISO]
- epithelial-mesenchymal cell signaling [ISO]
- establishment of Golgi localization [IMP]
- establishment of cell polarity [TAS]
- establishment or maintenance of apical/basal cell polarity [ISO]
- filopodium assembly [ISO]
- hair follicle morphogenesis [ISO]
- hair follicle placode formation [ISO]
- heart contraction [ISO]
- keratinization [ISO]
- keratinocyte development [ISO]
- multicellular organism growth [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron fate determination [ISO]
- nuclear migration [ISO]
- nucleus localization [ISO]
- organelle transport along microtubule [IMP]
- positive regulation of DNA replication [IMP]
- positive regulation of JNK cascade [IDA]
- positive regulation of MAPK cascade [ISO]
- positive regulation of cytokinesis [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of hair follicle cell proliferation [ISO]
- positive regulation of intracellular protein transport [IMP]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of pseudopodium assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO, ISS]
- positive regulation of synapse structural plasticity [IMP]
- regulation of attachment of spindle microtubules to kinetochore [ISO, ISS]
- regulation of exocytosis [TAS]
- regulation of filopodium assembly [ISO, ISS]
- regulation of mitosis [ISO]
- regulation of protein catabolic process [ISO]
- regulation of protein heterodimerization activity [ISO]
- regulation of protein kinase activity [ISO]
- regulation of protein metabolic process [ISO]
- regulation of protein stability [ISO]
- response to glucose [TAS]
- single organismal cell-cell adhesion [ISO]
- sprouting angiogenesis [IMP]
- submandibular salivary gland formation [IEP]
- substantia nigra development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [IDA]
- apical part of cell [ISO]
- cell [ISO]
- cell periphery [ISO]
- cell projection [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytosol [TAS]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [ISO]
- leading edge membrane [ISO]
- membrane [ISO, ISS]
- midbody [ISO, ISS]
- mitotic spindle [ISO, ISS]
- myelin sheath [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- plasma membrane [IDA, ISO]
- secretory granule [IDA]
- spindle midzone [ISO, ISS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets.
The brain-enriched p21cdc42/rac1-activated serine/threonine kinase, p65PAK, was identified and purified on the basis of overlays with [gamma-32P]GTP-Cdc42 onto SDS-fractionated proteins (Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., and Lim, L. (1994) Nature 367, 40-46). In this study, the ubiquitously expressed p21cdc42/rac1 binding protein with relative molecular weight of 62,000 was purified from rat testes and shown to contain peptides ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC42 PAK2 | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | Low | - | BioGRID | - |
Curated By
- BioGRID